Question

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2. 10-points: The MN blood group in humans is under the control of a pair of co-dominant alleles LM and LN. I a group of 556 Individuals, the following genotypic frequencies are found: 167 MM 280 MN 109 NN a) Calculate the frequency of the LM and LN alleles

Answer 1

Answer:

167 MM = 2 * 167 = 334 “M” alleles

109 NN = 218 “N” alleles

MN 280 = 280 “M” and 280“N” alleles

Total alleles = 1112

Frequency of “M” allele = 334+280 / 1112 =0.55

Frequency of “N” allele = 280+218/1112 = 0.45

Three expected genotypes are produced as follows.

Total population = 556

MM individuals = 0.55*0.55*556 = 168

NN individuals = 0.45*0.45*556 = 113

MN individuals = 2*0.55*0.45*556 = 275

Phenotype	Observed(O)	Expected (E)	O-E	(O-E)2	(O-E)2/E
MM	167	168	-1	1.00	0.0060
MN	280	275	5	25.00	0.0909
NN	109	113	-4	16.00	0.1416
Total	556	556			0.2385

Ch-square value = 0.2385

Degrees of Freedom = 1

Critical value = 3.84

The chi-square value of 0.2385 is less than the critical value of 3.84. Hence, the null hypothesis is accepted and the data is in Hardy-Weinberg equilibrium.