Question

13. Collagen conteins 2 amino acids that are modified post- translationally by different enzymes, both of which use vitamin C as a co-factor Collagen in different tissues including bone, cartilage, connective tissue and muscle varies in the proportion of these modified amino acids. The diagram shows the location of these tissues in a human knee and lower jaw. both - Trol mucus membrane -containing Bonnective -bore cartiago skin containing cornecivessive skin containing connective periodontal ligements maintaining the tissue bone Symptoms of vitamin C deficiency including bleeding gums and mucus membranes, poor skin healing and loss of teeth. In which type of tissue does collagen with modifiec amino acds occur most frequently? A Bone B Cartilage C Connective tissue D Muscle

Answer 1

Collagen also has 2 uncommon derivative amino acids which aren't specifically inserted during translation. These amino acids are actually located at particular spots relative to glycine and are actually modified post translationally by several enzymes, each of which involve vitamin C as a cofactor.

Hydroxyproline is actually produced from proline and Hydroxylysine derived from lysine. Based on the collagen type, different amounts of hydroxylysines are actually glycosylated (mostly having disaccharides attached).

As is actually apparent from the actions of collagen synthesis, Vitamin C forms a crucial element of the progression. Vitamin C deficiency causes scurvy, a painful and serious illness in which the collagen which is actually synthesized is actually defective and it doesn't take strong connective tissues. This results in bleeding and peeling gums, loss of teeth, non healing wounds and skin discoloration.

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