Question

What are the cellular consequences if Kinesin fails too bind to a microtubule properly/dissociates from the microtubule?

Answer 1

Kinesin is a motor protein which traverse across the microtubular proteins found in the cells. These proteins play a primary role in maintaining the movement of the microtubular arrangement in a cell. By virtue of the ATP-mediated biochemical energy provided to carry out this reaction, the potential energy of the phoshate bonds is converted into kinetic enery and the protien traverses on the surface of microtubule. Importantly, the kinesin-movement across the microtubule on the positive end only.

This has also been shown that binding of the kinesin protein to the microtubular assembly during cell cycle plays a critical role in promoting movement of the spindle and the chromosome across the spindle fibres. The association of the kinesin proteins with the spindle provides the kinetic energy for movement of the chromosomes in the metaphase. Thus, kinesin proteins are extremely important for these cellular events and failure of binding of kinesin to microtubules will result in failure of proper cellular division.