Question

Can someone please explain to me how the inactivation of GSK3 leads to the promotion of glycogen synthesis? I don't need to know about the pathway that occurs before, I just need to know whether the phosphorylation of glycogen synthase A or B stimulates glycogen synthesis, and what states they normally exist in.

Glycolysis Insulin Phosphoserines near carboxyl terminus 3ADP ЗАТР ADP GSK3 СКІ ATP АТР HOT HOHOHO HO Glycogen synthase Glycogen synthase b Inactive 1 1 Active 3P: PP1 Glucagon, Insulin Glucose 6-phosphate Glucose epinephrine

Answer 1

glycogen synthase kinase 3 phosphorylates the glycogen synthase a and converts it to the inactive form glycogen synthase b, so the active glycogen synthase can inhibit the glycogen synthesis if the glycogen synthase kinase is inhibited , the protein phosphatase can remove the phosphate groups from the inactive glycogen synthase b and convert it to active glycogen synthase a, so that glycogen synthesis occurs.

that is phosphorylation of glycogen synthase A inhibits glycogen synthesis.

the form of glycogen synthase depends on the signals, the insulin inhibits GSK3 so the levels of glycogen synthase a increases, glycogen synthesis increases and glucagon inhibits PP1, which removes the phosphate group from the glycogen synthase b and activates it so that the levels of glycogen synthase b increase, so glycogen is not synthesized.