Question

In the first stage of RNA interference, a __________ RNA precursor is cleaved by the _________ enzyme. The cleaved molecules are approximately _________ (insert number) bases in length and are called ___RNA if the RNA originated from a virus or ___RNA if the RNA was of endogenous origin ( if the RNA precursor was produced artificially, it's called ___RNA. The cleaved RNA is then separated into _____________ RNA, which then binds to the ribonuclease complex called __________. The short RNA molecule can then target the complex to ___RNA with a ________________ sequence, which is then cut at that site.

WORD BANK: Can be used more that once or not at all

RNAi, mi, m , RISC, sh, complementary, si, r, dicer, double-stranded, identical, hp, t, single-stranded

Answer 1

In the first stage of RNA interference, a ____Double stranded______ RNA precursor is cleaved by the ___dicer_____ enzyme. The cleaved molecules are approximately ___ 20-25______ (insert number) bases in length and are called _si__RNA if the RNA originated from a virus or _mi__RNA if the RNA was of endogenous origin ( if the RNA precursor was produced artificially, it's called _sh__RNA. The cleaved RNA is then separated into ____guide_________ RNA, which then binds to the ribonuclease complex called ___RISC_______. The short RNA molecule can then target the complex to _m_RNA with a ___complementary identical__ sequence, which is then cut at that site.