ZuoTi.Pro
Question

You have just discovered a new growth factor (NEF) that binds to a tyrosine kinase receptor...

You have just discovered a new growth factor (NEF) that binds to a tyrosine kinase receptor in nerve cells. The amount of diacylglycerol in the plasma membrane increases in cells expressing this receptor when treated with treated with NEF. Propose and simple signaling pathway and identify any isoforms of possible participating enzymes. Would you expect the concentrations of any other common second messenger to increase on NEF treatment?

science   biology   
0 0
Add a comment Improve this question Transcribed image text
Next > < Previous
Sort answers by oldest

Homework Answers

Answer #1

NEF Lgan d binding Site Ginge Si te Fust on bindn g NE F Cytosolic demain of RTk3 fo fether which ten phoaphesupate each othen on eic domain Kinages en Incsrease Dia , the phos photipaec. which cleave P P 3. alo mest eage So. Concentstation of

0 0
Add a comment
Know the answer?
Add Answer to:
You have just discovered a new growth factor (NEF) that binds to a tyrosine kinase receptor...
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions

  • Place the following events in Receptor Tyrosine Kinase signaling in order from the point when the...

    Place the following events in Receptor Tyrosine Kinase signaling in order from the point when the RTK binds it ligand. A.) An SH2 domain proteins is recruited to phosphotyrosine residues B.) cytoplasmic tails of the RTKs cross-phosphorylate C.) RAS-GEF catalyzes GTP exchange on RAS D.) Receptors dimerize in the plasma membrane

  • 14. You are studying a newly discovered growth factor. You find that this growth factor stimulates...

    14. You are studying a newly discovered growth factor. You find that this growth factor stimulates the proliferation of cells grown in the laboratory. You have also found that the receptor that binds the growth factor is a receptor kinase that activates Ras, which activates the MAP kinase pathway. Which mutations affecting this growth factor pathway would you expect to promote uncontrolled cell proliferation? Select all that apply. A. a mutation that inactivates the phosphatase that dephosphorylates the activated receptor...

  • 14 Biochemistry of Membrane Receptors 2nd October 2019 5. Lipid Signaling You are studying the signaling...

    14 Biochemistry of Membrane Receptors 2nd October 2019 5. Lipid Signaling You are studying the signaling pathway of basic fibroblast growth factor (bFGF), which binds to a receptor tyrosine kinase. You find that the amount of arachidonic acid in the cell increases when cells are treated with bFGF. a) Draw basic signaling mechanism that will result in this effect; include in your drawing the lipid substrate(s) and product(s) released based on their chemical structure and the enzyme(s) involved. (3 points)

  • Pertuzumab is a recombinant monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2)...

    Pertuzumab is a recombinant monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) protein. Pertuzumab can be used in the treatment of specific metastatic breast cancers in patients who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. The HER signaling pathway plays a role in the formation and growth of numerous cancers, and pertuzumab binds to the HER2 receptor to inhibit the ability of HER2 to interact with other HER family members on the...

  • Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA...

    Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA binding site 3. Erk lives in the cytosol 4. P-Erk lives in the nucleus 5. Ras (which is a completely different protein than Ras-GEF) is a GTPase switch so on with GTP and off with GDP 6. Ras-GDP is located at the plasma membrane 7. TrkA has an amino acid that can have a phosphate group added to it (a phosphorylation site) 8. TrkA...

  • 5. (12pts) You have discovered a novel cell-signaling pathway, in which cells stimulated with a hormone, Simpson, leads to a cell death response. The pathway involves 5 proteins with the following si...

    5. (12pts) You have discovered a novel cell-signaling pathway, in which cells stimulated with a hormone, Simpson, leads to a cell death response. The pathway involves 5 proteins with the following signaling: Simpson (signal) Homer --I Marge > Bart Lisa MaggieCell growth (response) A. Do you expect the Simpson stimulus to lead to increased or decreased levels of cell growth? Please provide your reasoning. B. You construct a series of cell lines with mutations in each one of these genes...

  • 32. Study the signaling pathway illustrated below, which involves two different receptors. Assume that a protein...

    32. Study the signaling pathway illustrated below, which involves two different receptors. Assume that a protein is active only when it is activated, but not inhibited, by its upstream signaling molecules. Activation and inhibition are indicated by normal and blunt arrows, respectively. Assume that the transcription regulator can be activated by either the binding protein or the kinase that are immediately upstream of the transcription factor. Under which of the following conditions will the expression of target:gene "X" be induced?...

  • Name 2ors L! You are inte finding protein are interested in understanding how Top5 expression is...

    Name 2ors L! You are inte finding protein are interested in understanding how Top5 expression is regulated. Top5 is a microtubule protein. You study a cell line where Top5 expression is controlled by a signal, Ligl. When hinds to and activates the membrane bound recentor it activates the Ras protein, which activates atein kinase called PKF, which then phosphorylates Grp4 on T224. Grp4 is a gene regulatory Wotein that can only enter the nucleus when phosphorylated: Thos is not expressed...

  • QUESTION 6 Which of the following is/are likely to elicit a rapid, reversible response? O An...

    QUESTION 6 Which of the following is/are likely to elicit a rapid, reversible response? O An odorant that binds to a G protein-coupled receptor O A growth factor that binds to a receptor tyrosine kinase o Asteroid hormone O Both GPCR and growth factor signaling QUESTION 7 Which of the following best explains why we can safely say, "Diamonds are forever"? O The conversion of diamonds into charcoal has an extremely high activation energy. O The conversion of diamonds into...

  • Question 10-12 10. During the mating process, yeast cells respond to pheromones secreted by other yeast...

    Question 10-12 10. During the mating process, yeast cells respond to pheromones secreted by other yeast cells. These pheromones bind GPCRs on the surface of the responding cell and lead to the activation of proteins inside the cell. When a wild-type yeast cell senses the pheromone, its physiology changes in preparation for mating: the cell stops growing until it finds a mating partner. If yeast cells do not undergo the appropriate response after sensing a pheromone, they are considered sterile....

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT