Question

2. Which compound is expected to be the most reactive for nucleophilic acyl substitution? 3. What is the correct name of the following compound be COCH2CH2CH3 (A) propyl 4-methylhexanoate (B) propyl 5-methylhexanoate (C) propanol 4-methylhexanoic acid (D) propyl 2-methylhexanoate 4. Which ester is expected to react fastest when hydrolyzed with aqueous base? homosan hoor hoon mootto OCH3

Answer 1

In nucleophillic acyl substitution, nucleophile attack on acyl group & remove leaving group. 1.2. more the electrophillic nature of carbonyl group, Cluster would be nudeophiles acyl сці і гол- i fo-cato a l le Due to delocalization - decrease so electrophillic character of carbon less reaction. xel - co - I having ewithelrawing nathe so increase the electrophillic Character of C. so full most reactive more so D option is or correct. on HelH₂ CH₃ 3 Correct Name & Propyl 5-methylhexanoate So B option is correct. During base hyclrolysis of ester, oh (nucleophile attack the carbonyl carbon (Electrophillic). Mall the electrophilicity of carbon , fastest would be hydrolysts. In option A, C, D, side alkyl group chawing e donating naturel so they decrease the electrophilic nature of Carbon. But in option B -(fy group having é withdrawing naturli & increase the electrophillic Character of carbon off more eletrophillic. so opHon B is colorect. of attack last.