In a paper recently published, the authors carried out the following synthesis. Draw the major products (Product A & Product B) that would form. Note: The first step (SOCl2, heat) is done under dilute conditions to prevent reaction between the product and other species in solution.
Homework Answers
first step is the acyl chloride
formation. The lone pairs of oxygen attacks the S of SOCl2 and the
Cl anion attacks to remove the OSOCl2 group. The one pair of
nitrogen attacks the carbonyl to form amide.
Then nitrogen of amine attacks the carbonyl of anhydride and thus acylation is done
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In a paper recently published, the authors carried out the
following synthesis. Draw the major products...
2. Provide missing conditions, reactants in the following synthesis. Propose the structures for Products A, B...
2. Provide missing conditions, reactants in the following synthesis. Propose the structures for Products A, B and C. Note: each step consists of more than one transformation. Step 1 Step 2 Hint: can use you 1. H, ethylene glycol, heat 2. NaOHH2o, heat 3. Н,о" Br Product A Step 3 HCI dilute PhMgBr, ether Product C Product B acetone 2. H,о" Step 1: Step 2: Step 3:
2. Provide missing conditions, reactants in the following synthesis. Propose the structures for Products A, B...
2. Provide missing conditions, reactants in the following synthesis. Propose the structures for Products A, B and C. Note: each step consists of more than one transformation. Step 1 in slope fin Step 2 Hint: you can use Br 1. H', ethylene glycol, heat 2. NaOH/H, O, heat 3. H30* Product A Step 3 HCl dilute Product C Product B 1. PhMgBr, ether 2. H20 acetone Step 1: Step 2: Step 3: 3. Show the full mechanism of Step 3...
29. Which are the major reaction products of the following reaction, which is carried out in...
29. Which are the major reaction products of the following reaction, which is carried out in an inert solvent? AICI: solvent NO2 Oló - o 02 a) I and II b) III and IV c) I and IV d) II and III 30. Which is the major product of the following reactions? CH3CI Cl2 K2Cr207 FeCl3 FeCl3 H2SO4 a) para-chlorobenzoic acid b) meta-chlorobenzoic acid c) a mixture of para- and meta-chlorobenzoic acid d) a mixture of ortho- and para-chlorobenzoic acid...
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clearer images For questions 1 - 5. predict the major organic products for the following transformations....
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For questions 1 - 5. predict the major organic products for the following transformations. Clearly indicate formal charges and stereochemistry if applicable. The use of a squiggly bond is not permitted; all stereoisomers should be clearly indicated for full credit. OH 1. a) Croy, H,SO,,H,O (Jones reagent) b) workup 2. a) HCI (cat.), CH, OH b) workup Q2 1. a) Croy, pyridine, HCl, solvent (PCC) b) workup 2. a) HCI (cat.), CH, OH b) workup a) NaOH, solvent,...
please help with how the flow chart will look like? thank you! Synthesis of n-Butyl Bromide...
please help with how the flow chart will look like? thank
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What are the desirable characteristics of a solvent to be used in the recrystallisation of a...
What are the desirable characteristics of a solvent to be used
in the recrystallisation of a solid product? (Hint: what is the
underlying purpose of doing recrystallisation, aside from making
the product look attractive?)
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2. Provide missing conditions, reactants in the following synthesis. Propose the structures for Products A, B and C. Note: each step consists of more than one transformation. Step 1 Step 2 Hint: can use you 1. H, ethylene glycol, heat 2. NaOHH2o, heat 3. Н,о" Br Product A Step 3 HCI dilute PhMgBr, ether Product C Product B acetone 2. H,о" Step 1: Step 2: Step 3:
2. Provide missing conditions, reactants in the following synthesis. Propose the structures for Products A, B and C. Note: each step consists of more than one transformation. Step 1 in slope fin Step 2 Hint: you can use Br 1. H', ethylene glycol, heat 2. NaOH/H, O, heat 3. H30* Product A Step 3 HCl dilute Product C Product B 1. PhMgBr, ether 2. H20 acetone Step 1: Step 2: Step 3: 3. Show the full mechanism of Step 3...
29. Which are the major reaction products of the following reaction, which is carried out in an inert solvent? AICI: solvent NO2 Oló - o 02 a) I and II b) III and IV c) I and IV d) II and III 30. Which is the major product of the following reactions? CH3CI Cl2 K2Cr207 FeCl3 FeCl3 H2SO4 a) para-chlorobenzoic acid b) meta-chlorobenzoic acid c) a mixture of para- and meta-chlorobenzoic acid d) a mixture of ortho- and para-chlorobenzoic acid...
1. An important paper published by Granchi et al. summarizes therapeutic potential of lactate dehydrogenase inhibitors (Curr Med Chem. 2010;17(7):672-97). Part of the abstract from this paper is shown below: Abstract: "In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic glycolysis, by catalyzing the reduction of pyruvate into lactate. This enzyme has recently received a great deal of attention since it may constitute a valid therapeutic target for diseases so different as malaria and cancer. In...
clearer images
For questions 1 - 5. predict the major organic products for the following transformations. Clearly indicate formal charges and stereochemistry if applicable. The use of a squiggly bond is not permitted; all stereoisomers should be clearly indicated for full credit. OH 1. a) Croy, H,SO,,H,O (Jones reagent) b) workup 2. a) HCI (cat.), CH, OH b) workup Q2 1. a) Croy, pyridine, HCl, solvent (PCC) b) workup 2. a) HCI (cat.), CH, OH b) workup a) NaOH, solvent,...
please help with how the flow chart will look like? thank
you!
Synthesis of n-Butyl Bromide Purpose of the Experiment: In this week's experiment you will be synthesizing n-butylbromide (IUPAC 1-bromobutane from 1-butanol and a concentrated acid via a nucleophilie substitution reaction. It is important to know that alcohols dehydrate to form alkenes in the presence of strong inorganic acids, so care must be taken in this experiment not to heat the reaction too vigorously else an elimination reaction may...
What are the desirable characteristics of a solvent to be used
in the recrystallisation of a solid product? (Hint: what is the
underlying purpose of doing recrystallisation, aside from making
the product look attractive?)
EXPERIMENT5 PREPARATION OF BENZOIC ACID Oxidation of a Primary Alcohol In this experiment, a primary alcohol (benzyl alcohol) is oxidised to a carboxylic acid (benzoic acid) by a strong oxidising agent (potassium permanganate) Because the synthesis reaction is carried out in basic conditions, the carboxylic acid...
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1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
myofiber in a human....
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