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To deal with the ABO blood type incompatibility, you decide to inactivate the “I gene” (“ABO...

To deal with the ABO blood type incompatibility, you decide to inactivate the “I gene” (“ABO gene”) using CRISPR. You inject Cas9 and a guide RNA for the middle of the I gene coding region into differentiated red blood cells (RBCs) from the blood. Will this make these RBCs compatible for all recipients? Why or why not?

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This process will make the blood compatible for all the recipients. This is because we have inactivated the gene which encodes for the antigen present on the surface of RBC of different individuals. This antigen is responsible for determining the type of blood present in a person. If this antigen is absent in any of the blood types, then if this blood type is transfused into any person, then no antibodies will be formed against this blood type because of the presence of antigen.

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