you decide to engineer blood stem cells with a mutant gene for the “BLT protein” that...
you decide to engineer blood stem cells with a mutant gene for the “BLT protein” that is found in RBC membranes and which is attached to the ABO sugars. Propose a DNA change you could make anywhere except the protein-coding region of the BLT gene that would result in RBCs with no AB sugars. Explain the change in 1-3 sentences
Homework Answers
A site directed mutagenesis needs to be made in the promoter region of the BLT gene. For example, if a mutation is made in the crucial -10 or -35 region of the promoter to which RNA polymerase and CBP binds, then transcription of BLT gene will not take place. This would make the RBCs produced unable to bind to ABO sugars.
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you decide to engineer blood stem cells with a mutant gene for
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