The transport system that conveys malate and alpha-ketoglutarate across the inner mitochondrial membrane is inhibited by...
The transport system that conveys malate and alpha-ketoglutarate across the inner mitochondrial membrane is inhibited by n-butylmalonate. Suppose n-butylmalonate is added to an aerobic suspension of kidney cells using glucose exclusively as fuel. Predict the effect of this inhibitor on:
a) Glycolysis
b) Oxygen consumption
c) Lactate formation
d) ATP synthesis
Homework Answers
Ans:
(a) When n -butylmalonate an inhibitor of the malate-oaa shuttle, is added to kidney cells in presence of glucose, NADH accumulates in the cytosol as a result glycolysis operate anaerobically.
(b) Due to the inhibitor an increased rate of fructose diphosphate and fructose-6-P recycling, resulting in a wasteful use of ATP, for the maintenance of high oxygen consumption rates despite decreased net glucose formation.
(c) Lactate formation increase.
(d) as NADH accumulates in cytosol cannot get in the mitochodria for ETC so ATP synthesis is also decrease.
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The transport system that conveys malate and alpha-ketoglutarate
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Q2.
The release of ATP by the beta subunit is most directly
dependent on:
Select ONE option:
1. the flow of protons from the intermembrane space to the
matrix.
2. the rotation of the c-ring in the membrane.
3. the passage of electrons along the electron transport
chain.
4. a conformational change in the beta subunit.
Q3.
What defines the direction of rotation of the c-ring in the F0
complex?
(Select ALL that apply.)
1. Amino acids side chains in...
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please label important parts.
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