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Why is the flip-flop of phospholipids from one monolayer to another monolayer so rare?

Why is the flip-flop of phospholipids from one monolayer to another monolayer so rare?

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Answer #1
  • The movement of molecules transversely from one side to the other side of the membrane is known as flip-flop.
  • Flip-flop of the phospholipids is very rare and at lower rate when compared to lateral diffusion.
  • This is because transverse diffusion need to overcome high-energy barrier. Also, the polar region of molecules moves to the hydrophobic core of membrane.
  • The polar region of phospholipids is small when compared to the proteins, and hence it flip flops occassionally.
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