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2) There are numerous targeted therapies aimed at each of the hallmarks, but the soberly reality...

2) There are numerous targeted therapies aimed at each of the hallmarks, but the soberly reality is that most target therapies do not work very long. For example, Epidermal Growth Factor Receptor (EGFR) inhibitors are effective for a while. Why is that so? Guide: Consider what could be responses from the tumor cells as well as the effect of neighboring cells.

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Ans. The major reason rendering the target therapy inefficient is the continous mutation of the target cell. Owing to which the targetted therapy would not be able to ellicit the similar effect which it use to impart previously. In case of tumor cells the change in signalling system has been a major contributor to such response.

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