A single point mutation in a gene results in a nonfunctional protein. Individuals heterozygous for this mutation were identified using a Southern blot. Which pair of wild-type (WT) and mutant alleles most likely contains the mutation? Why is " A" the correct Answer. Can you please explain. Thank you! Step by step.
Homework Answers
All options A, B, C will have mutation for sure but in case of option D, mutation may or may not happen because only 3rd nucleotide of a codon is changed (if u have provided the question with correct reading frame) because of degeneracy.
Option A is the correct answer because the single point mutation is occurring in the middle of a codon which will lead to formation of different amino acid and hence a dysfunctional protein. And also ATG or AUG (it is getting mutated from AAG to ATG) is the start codon which is not the case in option B and C even if the mutation is happening.
probability of getting a dysfunctional protein in descending order is
Option A>> Option C>> Option B>> Option D
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Do you expect a Pro→Gly mutation in a surface-loop region of a
globular protein to be stabilizing or destabilizing? Assume the
mutant folds to a native-like conformation. Explain your answer in
terms of the predicted enthalpic and entropic
effects of the mutation on the ΔG for protein folding compared to
ΔG of folding for the wild-type protein.
Match the items in the left column to the appropriate blanks in
the sentences on the right.
ASsolvent Because the mutation is on...
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