Question

The process of homologous recombination is a means to repair double-strand breaks, the most lethal form of DNA damage. Arrange the sequence of events in the proper order: 1. ATR recognizes single-stranded ends, binds to them, and initiates signaling. 2. RAD51 complexes with ssDNA and searches for homologous sequences. 3. MRN nuclease trims the 5' ends, leaving ss-3' ends that are coated with replication protein A. 4. ATM activates a nuclease in MRN and signals downstream effectors. 5. RAD51-ssDNA complex invades undamaged homologous DNA. 6. DNA synthesis and cutting ensues, resulting in either recombinant or nonrecombinant chromosomes. ► View Available Hint(s) O 4, 2, 5, 3, 1,6 4, 5, 1, 2, 3,6 O 4, 2, 1, 3, 5, 6 o 4, 3, 1, 2, 5, 6

Answer 1

Ans. 4,2,5,3,1,6

(4) ATM activatesa nuclease in MRN and signals downstream effectors.

(2) RAD51 complexes with ssDNA and searches for homologous sequences.

(5) RAD51- ssDNA complexe invades undamaged homologous DNA.

(3) MRN nuclease trims the 5' ends, leaving ss-3' ends that are coated with replication protein A.

(1) ATR recognize single- stranded ends, binds to them, and initiates signaling.

(6) DNA synthesis and cutting ensues, resulting either recombinant r nondenominant chromosomes.