Question

3. Which of the following compounds are major ligands for receptor tyrosine kinases (RTKs)? E. Growth factors F. Hormones G. Interferons H. Cytokines Explain the mechanism of activation of RTKs in cell: 4. Which domain of the transcription factor ELK-1 is responsible for binding to DNA? A. A B. B C. C D. D Explain mechanism of activation of ELK-1 by MAPK:

Please answer these questions correctly!

Answer 1

Answer= 3.

The compounds that are major ligands for receptor tyrosine kinases (RTKs) are:

E.Growth factors

F.Hormones

Explanation - The ligands for receptor tyrosine kinases (RTKs) are hormones like as insulin and various Growth factors like as Epidermal growth factor(EGF) , Transforming growth factor, Platelet derived growth factor, Fibroblast growth factor and colony stimulating factor.

Mechanism activation of RTK in cell as follows:

ligand -ligand-binding site, Plasma membrane Exte cioe cytosolie Içkinase a domain D catalytic | igte ATP ADP e Hocytosol

1. All RTKs consists of Extracellular domain containing a ligand binding site , a single hydrophobic transmembrane alpha helix , and a cytosolic domain that includes a region with protein tyrosine kinase activity.
2. ligand binding causes a conformational change that promotes the formation of a functional dimeric receptor, bringing together two intrinsic or associated kinases.
3. Which then phosphorylates each other on a tyrosine residue in the cytosolic domain .
4. The activated kinases then phosphorylates other tyrosine residues in the cytosolic domain.
5. The resulting phosphotyrosines function as docking sites for various signal -transduction protein.