Question

Glucagon can induce several changes in second messengers that alter cellular metabolism. Which changes in second...

Glucagon can induce several changes in second messengers that alter cellular metabolism.

Which changes in second messenger(s) are correct?

A. Acetylation of Insulin receptor

B. Synthesis of cNAD+

C. Depilitation of

Insulin

Receptor

D.

Altering the Km for insulin binding to Insulin Receptor

E. Induction of cAMP and phosphorylation of Phosphorylase A

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Answer #1

Glucagon is a pancreatic hormone produced by alpha cells of islets of Langerhans. It is responsible for gluconeogenesis and glycogenolysis. This hormone induces several changes in second messengers which alter the cellular metabolism. Out of many, cyclic AMP (cAMP) is the most important and it's it's induction leads to the formation of more than more glucose in liver. Therefore, the correct answer is option E i.e. induction of cAMP and phosphorylation of phosphorylase A which aids in the above mentioned processes.

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