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Which are true about direct repair of DNA? O The damaged base is excised and a new segment of DNA is synthesized to fill in t

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Q. Which are true about direct repair of DNA ?

a. The damage base is excised and a new segment of DNA is synthesized to fill in gap.

b. Error-prone DNA polymerases are used to insert a nucleotide opposite to the damaged base.

c. A damaged base is restored to its correct structure without removing it from the DNA.

d. DNA ligase is needed.

e. Methylation marks can be used to distinguish the correct strand from incorrect strand.

Ans. c. A damaged base is restored to its correct structure without removing it from the DNA.

Description: Direct repair of DNA: various types of damage are repaired without removing base or nucleotide. The best example of direct repair of DNA is photoreactivation of cyclobutane pyrimidine dimers. The reaction promoted by DNA photolyases. The pyrimidine dimers consequence from UV induced reaction and photolyases used energy derived from absorbed light to reverse the damage. Photolyases generally contain two cofactors that is light absorbing agents and chromophores.

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