The interface between DNA and histone has multiple contacts. (T/F)
The interface between DNA and histone has multiple contacts. (T/F)
Homework Answers
The interface between DNA and histone has multiple contacts = TRUE
Histones are positively charge proteins, and DNA is negatively charge molecule. DNA is pack around histone octamer, this octamer composed of H2A, H2B, H3 and H4. DNA pack around each octamer with 1.75 round, so that it has multiple contacts with histone proteins.
In eukaryotes, genomic DNA is wrapped around the histone complex to make chromatin. The direct contacts...
In eukaryotes, genomic DNA is wrapped around the histone complex to make chromatin. The direct contacts between DNA and the histone beads interfere bindings of the transcriptional factor proteins to their cognate sequence elements, decreasing gene activities. To increase transcriptional activity of the affected genes, the RSC/CRC complex remodels chromatins such that the ________ sequences can be amenable to formation of the transcriptional initiation complex. Select one: a. TBP-binding and TAP-binding b. Shine-Dalgarno c. start codons d. All of these...
True/False (6 pts) *if false, correct the statement 1. (True/False) The histone octamer forms a protein...
True/False (6 pts) *if false, correct the statement 1. (True/False) The histone octamer forms a protein core around which the double stranded DNA is wound. 2. (True/False) Histones are highly variable proteins across organisms. 3. (True/False) The interface between DNA and histone has multiple contacts. 4. (True/False) CTCF is a cis-regulatory element that acts as a silencer. 5. (True/False) The modification cytosine to 5-methyl cytosine is associated with gene inactivation and reduced gene expression. 6. (True/False) HATs and HDACs are...
The physical association between the histone octamer and DNA can be disrupted in numerous ways.What are...
The physical association between the histone octamer and DNA can be disrupted in numerous ways.What are they?
5. What is the connection between DNA methylation, histone deacetylation, and gene regulation in eukaryotes?
5. What is the connection between DNA methylation, histone deacetylation, and gene regulation in eukaryotes?
You are interested in the interactions of histone deacetylase (HDAC) with nucleosomes. Using a DNA template...
You are interested in the interactions of histone deacetylase
(HDAC) with nucleosomes. Using a DNA template that is end labelled
with 32P and has two nucleosomes already bound to it, you perform a
gel-shift experiment with HDAC and the chromatin from above. You
also assemble chromatin with nucleosomes that have been methylated
at a particular amino acid residue of Histone H4. The results are
below. Based on the data, (A) explain the autoradiogram below –
what are all the bands?...
What all is true about Interfaces in Java? An interface contains function definitions (T/F) An interface...
What all is true about Interfaces in Java? An interface contains function definitions (T/F) An interface contains function prototypes (T/F) A class extends an interface (T/F) A class implements an interface (T/F) An object reference can be of type interface (T/F) It is possible to make an object that's purely an interface type (T/F)
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______...
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______ a) meiosis b) mitosis c) both 3. Homologous recombination in meiosis has the main purpose of_____ a) DNA repair b) Creating new chromosomes c) Sealing double-stranded breaks 4. Strand invasion usually happens without enzymatic assistance. T/F? 5. When replication fork runs into a nick, it results in a_______ a) single-stranded break b) double-stranded break 6. The invading end is usually a _______ a) 3'...
1. What are the structures of chromosomes 2. Identify the components of a histone core and...
1. What are the structures of chromosomes 2. Identify the components of a histone core and describe how a nucleosome is assembled 3. Define the term “histone code”. 4. Identify common histone markers of hetero- and euchromatin. 5. Explain the relationship between methylated DNA and chromatin. 6. Identify types of enzymes involved in chromatin regulation 7. What type of data one can get from chromosome conformation capture (3C). 8. What type of data one can get from ChIP-Seq. 9. What...
On a planet other than earth, an organism has DNA with a left handed double helix...
On a planet other than earth, an organism has DNA with a left handed double helix with a rise of 0.61 A and a helical pitch of 9.76 A. When the DNA wraps around a histone 181 bases of DNA surround the histone and each nucleosome is separated by 121 bases of DNA. How many bases are found in a single pitch ( one turn of DNA ) ?
32. Unknown DNA was analyzed and the result showed the nucleotide composition as follows: A T...
32. Unknown DNA was analyzed and the result showed the nucleotide composition as follows: A T C Composition % 21 21.5 38.5 What does the analysis reveal about DNA structure and why? (3 pt) 19 33. During chromatin remodeling DNA must be replicated as well as histone proteins. List (no explanation) the enzymes involved in chromatin remodeling (3 pt).
True/False (6 pts) *if false, correct the statement 1. (True/False) The histone octamer forms a protein core around which the double stranded DNA is wound. 2. (True/False) Histones are highly variable proteins across organisms. 3. (True/False) The interface between DNA and histone has multiple contacts. 4. (True/False) CTCF is a cis-regulatory element that acts as a silencer. 5. (True/False) The modification cytosine to 5-methyl cytosine is associated with gene inactivation and reduced gene expression. 6. (True/False) HATs and HDACs are...
5. What is the connection between DNA methylation, histone deacetylation, and gene regulation in eukaryotes?
You are interested in the interactions of histone deacetylase
(HDAC) with nucleosomes. Using a DNA template that is end labelled
with 32P and has two nucleosomes already bound to it, you perform a
gel-shift experiment with HDAC and the chromatin from above. You
also assemble chromatin with nucleosomes that have been methylated
at a particular amino acid residue of Histone H4. The results are
below. Based on the data, (A) explain the autoradiogram below –
what are all the bands?...
32. Unknown DNA was analyzed and the result showed the nucleotide composition as follows: A T C Composition % 21 21.5 38.5 What does the analysis reveal about DNA structure and why? (3 pt) 19 33. During chromatin remodeling DNA must be replicated as well as histone proteins. List (no explanation) the enzymes involved in chromatin remodeling (3 pt).
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