2. During exercise, skeletal muscle generates lactate by anaerobic glycolysis. Lactate enters the blood stream and...
2. During exercise, skeletal muscle generates lactate by anaerobic glycolysis. Lactate enters the blood stream and is taken up by the liver, which recycles it back to glucose through gluconeogenesis. This is known as the Cori cycle. Determine the energetic cost of maintaining glucose to the muscle by this mechanism.
OPTIONS ARE:
-6
-4
-2
0
+2
+4
+6
| Pathway | ATP generated | ATP/GTP consumed | Net ATP/GTP |
| Glucose -> lactate | |||
| Lactate -> glucose | |||
| Net ATP/GTP |
Homework Answers
Glucose to lactate formation - ATP generated -04, ATP consumed- 2, net ATP = +02 (gain)
Lactate to glucose formation-ATP generated -0, ATP consumed- 06, net ATP= -6 (consumed)
So net ATP cost= -6+ 2= -4 (consumed) which is energy cost. So option 2nd is correct -4.
Hope it's clear..thanks
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2. During exercise, skeletal muscle generates lactate by
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In the Cori cycle, when glucose is degraded by glycolysis to
lactate in muscle, the lactate is excreted into the blood and
returns to the liver where it is converted back into glucose by
gluconeogenesis. For each enzyme below, identify whether it is
involved in the glycolysis pathyway, gluconeogenesis pathway, both
pathways or neither pathway.
n the Cori cycle, when glucose is degraded by glycolysis to lactate in muscle the lactate is excreted into MapdEb the blood and returns to...
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