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In skeletal muscle under anaerobic conditions, pyruvate is further reduced to lactate. What is the net...

In skeletal muscle under anaerobic conditions, pyruvate is further reduced to lactate. What is the net equation for the payoff phase of glycolysis?

glyceraldehyde-3-phosphate + 2 ATP + Pi ---> lactone + NAD+

glucose+2ATP ---> 2Glyceraldehyde-3-Phosphate + 2ADP + 2H+

2glyceraldehyde-3-phosphate + 4ADP + 2Pi >2Lactate + 4ATP

None of the above
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Answer #1

Answer: 2glyceraldehyde-3-phosphate + 4ADP + 2Pi >2Lactate + 4ATP

During the Pay-off phase of glycolysis, two glyceraldehyde-3-phosphate are the starting substrates. A total of four ADP are utilized in substrate level phosphorylation to produce 4ATP. The 2 Pi (inorganic phosphates) are used in the step where the two Glyceraldehyde-3-phosphate molecules are converted to two molecules of 1,3-bisphosphoglycerate by the enzyme Glyceraldehyde-3-phosphate dehydrogenase. The NADH produced are consumed in fermentation and hence are not present in the overall reaction where pyruvate is converted to lactate by the enzyme lactate dehydrogenase.

All other options show incorrect stoichiometry or substrates/products.

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