Question

Create a metabolic pathway map that shows what happens to a glucose molecule that enters a muscle cell and becomes metabolized to lactate (in Oz-depleted muscle). Follow the lactate through the Cori cycle, and show how it ultimately gets converted to a glucose molecule that can once again enter the muscle cell. In addition, show how the glucose may be stored as glycogen, and mobilized from glycogen in both liver and muscle. Also show how pyruvate gets converted to acetyl-CoA in aerobic muscle. All the pathway:s should be shown on the same page and correctly integrated with each other in order to emphasize the relationships between pathways. (The liver and muscle metabolic pathways should be shown separately, but within each organ, a given reaction should only be shown once.) Your map should include: a. Clear labels for all the metabolic pathways in your map (1 mark) b. All the pathways shown on the same page and correctly integrated with each other within the Cori cycle, i.e. it should be clear which reactions are shared by different pathways (2 marks) c. The names of all metabolites (common abbreviations may be used) (5 marks) d. The names of all enzymes (5 marks) e. All relevant cofactors/co-substrates discussed in class, clearly showing where ATP is used and produced (4 marks) f. Double or single arrows representing reversible or irreversible reactions, respectively (2 marks) g. All "high-energy" intermediates clearly labeled with an asterisk(3 marks) h. Labels for organ and intracellular locations of the pathways/reactions (2 marks)

Answer 1

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