Mutation that changes a codon in a gene to one of the three termination codon (UAA , UGA, or UAG) is called as nonsense mutation . GGA codes for glycine and if 1st G in the codon is substituted by U then it becomes UGA .
Since Guanine is substituted by uracil it means purine is replaced by a pYrimidine then it's a transversion.
4. A codon that specifies the amino acid Gly undergoes a single-base substitution to become a...
#1 Mutation 1. A chromosomes has the following segments, where represents the centromere: MNOPQRST Give the chromosome sequences that would result from the following mutations: a. Deletion of MN Pericentric inversion of NOP C. Inversion of RS, followed by tandem duplication of QRST b. 2. Which type(s) of chromosomal mutations: a. Increase the amount of genetic material in a particular chromosome? b. Increase the amount of genetic material in the entire genome? c. Decrease the amount of genetic material in...
1. Researchers discovered that a single amino acid change of cysteine to tryptophan in a transmembrane protein causes retinal degeneration. 1a. Using the genetic code, what mutant mRNA likely encodes this substitution and what is the WT mRNA sequence? (Indicate polarity) 1b. Is the substitution caused by a transition or transversion mutation?
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion, Frameshift mutation Label these genetic changes (a-e). More than one answer may apply to each answer. a. GC->CG in the protein coding region on a gene. b. GC->TA in a GAA glutamate codon c. Loss of three bases GAA for a glutamate codon d. GC->CG in a tRNA gene e. GC->AT in the ribosome binding site of a mRNA
3. A small peptide has the amino acid sequence Phe-Leu-Tyr-Ala-Leu-Gly-Glu. A shorter variant of this peptide was discovered that had the sequence Phe-Leu-Tyr-Ala; it was demonstrated that this shorter peptide was due to a single base substitution in the second Leu codon. What type of mutation (missense, nonsense, frameshift) gave rise to this shorter peptide? Which of the six possible Leu codons was used in the synthesis of the original (long) peptide (can you eliminate some as possibilities)?
Question 8 4 pts After a single base pair change, the following amino acid sequence was altered. Original amino acid sequence: Met-Glu-Tyr-Leu-Phe Altered amino acid sequence: Met-Glu-STOP What was the change that occurred in the TEMPLATE DNA STRAND? Substitution or Indel Transition or transversion (or NA) Nucleotide changed by If substitution: Original nucleotide and then new nucleotide If insertion: Nucleotide inserted and then write "inserted" in the second space If deletion: Nucleotide deleted, and then write "deleted"
10) The codon UCA specifies the amino acid serine. a) How many single nucleotide substitutions in this codon could result in chain termination? b) How many single nucleotide substitutions in this codon would fail to change the amino acid?
Please answer all.... Thank you! 81)If a polypeptide chain contains 600 amino acids, then the gene coding for this polypeptide must contain _____. 600 nucleotides 1200 nucleotides 1800 nucleotides 1800 codons 1800 anticodons More than one of the above are correct. 82) When we altered gene triplet in the DNA produces a chain-terminating codon in the mRNA, the (1pts) result is called a reverse mutation nonsense mutation missense mutation spontaneous mutation frameshift mutation 83) A single base substitution changes the...
1. What is the difference between a transition and a transversion? Which type of base substitution is more common? 2. What is the difference between a missense mutation and a nonsense mutation? Between a silent mutation and a neutral mutation?
A single mutation has occurred in the following DNA sequence. 5' ATG TTG GCC CAT 3' wild-type (normal) sequence 5' ATG TTG CCC CAT 3' mutant sequence (a) Identify and classify the mutation according to its molecular structure (i.e., insertion, deletion base substitution (transversion), or base substitution (transition)). Briefly explain why you selected this classification. (1.75 marks) (b) Identify and classify the mutation according to its functional effects (i.e., frameshift, missense, nonsense, or silent). Briefly explain why you...
Question Give an mRNA sequence that will code for synthesis of metenkephalin. Tyr-Gly-Gly-Phe-Met Select codons from the following table. If more than one codon is possible for a given amino acid, choose only one If there are fewer than 8 amino acids in the peptide, leave the corresponding codons blank. Enter your answer in ALL CAPS, ie, "ATG" not "atg" Third base (3" end) First base (5' end) Second baseUCAG Phe Phe Leu Leu SerSer Ser Ser U Leu Leu...