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Q1. Why do viruses have a high rate of mutation? Are all mutations that arise in viruses beneficial towards the virus spread?
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Viruses continuously change and evolve due to genetic selection and mutation. They undergo frequent mutations through recombination and exchange of genetic information to create a novel virus strain. RNA viruses have higher mutation rates than compared to DNA viruses. The DNA viruses have a low mutation rate because the replication enzyme DNA Polymerase has proofreading activity whereas in the case of RNA viruses the replication enzymes do not have a proofreading activity. These mutations can be deleterious, neutral or can even be beneficial. All the mutations that occur in the virus are not beneficial as few mutations also interfere with the essential functions of virus-like attachment, penetration, uncoating, replication, and assembly. only those mutation which does not interfere with the basic functioning of the virus persist in the virus population whereas the other mutations are eliminated via natural selection.

The high rate of mutation can lead to repetitive infection as random mutations in a virus can develop antiviral resistance and the creation of novel antigenic determinants.

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