The answer is A. Four beta (HbH) and four gamma (Hb Barts).
In alha thalassemia the production of alpha chains of globin protein is reduced. Due to the reduced production of alpha subunit, beta chains will be produced in excess amount in adults and gamma chains in new borns. The excess beta chain from the unstable tetramer is called as HbH and from the gamma chain is called as Hb Barts.
Question 28 What type of globin chains and hemoglobin are characteristics of severe alpha thalassemia? Four...
Alpha thalassemia is a blood condition resulting from abnormal hemoglobin production, due to loss of function of copies of either HBA1 or HBA2 genes. These genes are very similar, and for simplicity’s sake we talk about having four copies of the HBA gene (two copies of each). HBA1 and HBA2 genes are located next to each other, and therefore are described within the same allele. For example, αα indicates that both HBA1 and HBA2 copies on an allele are functioning,...
Question 22 The Sickle-cell defect occurs in which of the globin chains? o Gamma © Beta More than one answer is correct Delta O Alpha
Part 2. Adult hemoglobin is composed of two alpha subunits and two beta subunits. There are several genes that code for proteins closely related to beta globin. Each of Epsilon, Gamma, and Beta can all pair with Alpha globin to form functional hemoglobin. 1. Epsilon: expressed during early embryogenesis. 2. Gamma: expressed during later fetal development. 3. Beta: expressed after fetal development into adulthood All of the beta-family globin genes are regulated by a set of enhancer elements called the...
1.Hemoglobin is a complex protein that contains four polypeptide chains. The normal hemoglobin found in adults –called adult hemoglobin –consists of two alpha and two beta polypeptide chains, which are encoded by different loci. Sickle-cell hemoglobin, which causes sickle-cell anemia, arises from a mutation in the beta chain of adult hemoglobin. Adult hemoglobin and sickle-cell hemoglobindiffer in a single amino acid: the sixth amino acid from one end in adult hemoglobin is glutamic acid, whereas sickle-cell hemoglobin has valine at...
Human adult hemoglobin is a tetramer containing two alpha (α) and two beta (β) polypeptide chains. The α gene cluster on chromosome 16 and the β gene cluster on chromosome 11 share amino acid similarities such that 61 of the amino acids of the α-globin polypeptide (141 amino acids long) are shared in identical sequence with the β-globin polypeptide (146 amino acids long). How might one explain the existence of two polypeptides with partially shared function and structure on two...
Table 2. Results of blood and hemoglobin tests for case
study.
Subject
Blood type (phenotype)
Hemoglobin genotype
Mother
A+
HbAS
Baby
A+
HbAA
Male Subject
O-
HbAS
Based on your results shown in Table 2, can you exclude the
possibility of paternity? Cite the specific results
that allow you to make this claim
What are ALL of the potential genotypes for each subject based
on blood type?
Define the difference between genotype and phenotype.
Supplementary Information A gene is a...
Question 1 1 pts For aldol reactions, what type of hydrogens are required for formation of the enolate intermediate? beta hydrogens O carboxylic acid hydrogens alpha hydrogens O gamma hydrogens alcoffol hydrogens
Question 28 6 pts A) What are two characteristics of DNA and its structure that allow it to be replicated accurately?B) What term is used to describe the way DNA is replicated in a cell?
QUESTION 1: Total of 23 marks On 30 June 2020, Zeta Ltd owns shares in five investee companies, Alpha Ltd, Beta Ltd, Gamma Ltd, Delta Ltd, and Eta Ltd. Zeta Ltd owns 55% of the issued share capital of Alpha Ltd. Zeta Ltd's management indicates that Zeta Ltd has no intention of directing or interfering with the operations of Alpha Ltd. Zeta Ltd owns 20% of the issued share capital of Beta Ltd. The remaining shares of Beta Ltd are...
Question 30 1 pts What type of interaction would occur between the side chains of the two amino acids shown below? NH2-C=NH; CH CH₂ 0 NH₃ – CH-C-0 CH Сн, о NHz-CH-C-0 hydrophilic interaction hydrophobic interaction ion-ion attraction o disulfide bridge