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Question 22 The Sickle-cell defect occurs in which of the globin chains? o Gamma © Beta More than one answer is correct Delta
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The sickle-cell defect occurs in Beta globin chain.

Explanation : The hemoglobin protein is made up of two alpha chains and two beta chains. The single nucleotide mutation in the beta globin gene (GAG codon changes to GTG) results in substitution of glutamic acid by valine in 6th position. This defect causes the hemoglobin protein and form kind of stiff fibers. These fibers ultimately distort the normal shape of the RBCs to sickle shaped and make them more fragile.

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