1. which of the 3 drugs above have the highest binding affinity toward EGFR?
a. erlotinib
b. afatinib
c. gefitinib
In this context, Gefitinib and erlotinib are reversible inhibitors while afatinib is an irreversible inhibitor and it posses the higher affinity for EGFR kinase domain. It has been reported that afatinib promotes the most persistent inhibition. So, the correct answer is afatinib
1. which of the 3 drugs above have the highest binding affinity toward EGFR? a. erlotinib...
Explain how a chemical that blocks the binding of EGF to the EGFR would interfere with the replication of cancerous cells that overexpress EGFR. a) It will activate the EGFR pathway. b) It will block the EGFR pathway. c) It will have no effect and the EGFR pathway will continue normally d) It will lead to overexpression of the EGFR pathway
A. In the chart above, where the solid line represents the
binding affinity of hemoglobin for oxygen with NO drug treatment.
Which curve above (dotted or dashed) represents
the affinity of hemoglobin of oxygen after drug treatment?
Explain.
B. How does the drug effect hemoglobin’s affinity for
O2 and how would this achieve the desired patient
result?
Increases Affinity, Decreases Affinity, No Change to Affinity?
Explain.
With hospital funding going down, local hospitals are looking for any way to cut...
Which of the following have the highest electron affinity? Which of them has the strongest metallic character? Explain: Na, Mg, O, C, S
O2 binding to Fe2+ in one subunit of hemoglobin changes the binding affinity of the other 3 subunits. a. Describe the change in the shape of the heme that results in O2 binding. b. How is the heme shape change communicated to the other subunits c. What is the role of Bisphosphoglycerate (BPG) in hemoglobin mediated oxygen transport?
1. The term (affinity/potency) is used to describe the strength of a drug’s binding to receptors. Which is correct?
please explain
3) Consider this figure, which shows oxygen binding to hemoglobin under various conditions. 1.0 B 0.5 po2 a) If B is normal hemoglobin what could lead to curve hemoglobin A. (2 pt) b) If B is normal hemoglobin what could lead to curve hemoglobin C. (2 pt) c) Which curve shows the hemog Iobin with the highest O2 affinity? (2 pt) d) Which curve shows the hemoglobin with the lowest Pso? (2 pt) (Saturation
Which element in Group 6A has the highest electron affinity? Select one: a. O b. S c. Se d. Te e. Po
biochemistry
Question 2.(12 pts) O2 binding to Fe? in one subunit of hemoglobin changes the binding affinity of the other 3 subunits. a. Describe the change in the shape of the heme that results in O2 binding. Page 4/7 b. How is the heme shape change communicated to the other subunits c. What is the role of Bisphosphoglycerate (BPG) in hemoglobin mediated oxygen transport? Question 3.(9 pts) You need to make up a 600 ml of a 40 mM solution...
An atom of which of the following elements has the highest electron affinity? Select one: a. Br b. Cl c. Rb d. As e. Se An atom of which of the following elements is not diamagnetic in the ground state? Select one: a. Rn b. Ca c. Pt d. Cd e. All are diamagnetic. The general electron configuration for the outermost electrons of the halogens is Select one: a. ns2np4 b. ns2np5 c. ns2np6 d. ns2np2 e. ns2np3 What...
place in order drom lowest to highest electron affinity
The redox pairs below all participate in the transfer of electrons from FADHS to oxygen. (This is not an exhaustive list. The values of the standard blochemical reduction potentials (E") are provided. Use the reduction potentials to order these pairs from west to highest electron affinity, which translates from initial donor to final acceptor ubiquinone/ubiquinol +0.045 V FAD FADH2 -0.040 V cytochrome 1 (FeFe?) +0.220 V 1/02H₂O 0 816 V Initial...