1. Indicate which type of physical mutations (nonsense, missense-nonsynonymous, missense-synonymous, silent, polymorphism, frameshift) cause the following results:
A. Hypomorph
B. Amorph
C. Hypermorph
A Hypomorph
Hypomorphic mutations reduce but do not eliminate gene activity. An example is the apricot allele of the white gene. This mutation is recessive and results in apricot-colored eyes.
It causes a partial loss of gene function.
1. Indicate which type of physical mutations (nonsense, missense-nonsynonymous, missense-synonymous, silent, polymorphism, frameshift) cause the following...
What type of physical mutations are most likely to cause a hypomorph? O A nonsense O B missense C frameshift o D silent O E polymorphism
What type of physical mutations are most likely to cause an amorph? O A nonsense 0 B missense - nonsynomous 0 C missense - synomous O D silent O E polymorphism
Q12 Homework. Unanswered What type of physical mutations are most likely to cause a hypermorph? O A nonsense O B missense-nonsynomous O C missense - synomous o D silent O E polymorphism 0 F frameshift
Compare and contrast silent mutations, missense mutations, nonsense mutations, and frameshift mutations.
What type of physical mutation is least likely to affect gene function? A nonsense B missense - nonsynomous C missense - synomous D silent E polymorphism F frameshift
Q14 Homework. Unanswered What type of physical mutation would most likely occur as a result of X-ray exposure? o A nonsense 0 B missense - nonsynomous o C missense - synomous o D silent O E polymorphism O F frameshift
Q17 Homework – Unanswered What type of physical mutation would most likely occur as a result of exposure to Oxygen free-radicals? o A nonsense O B missense 0 C silent O D polymorphism O E frameshift
*Hint: You will have one of each type. Types of Mutations? Point - Missense Frameshift - Insertion Point - Nonsense Frameshift Deletion Point - Silent Original DNA Sequence: TACACCTTGGCGACT mRNA Sequence: AUG Amino Acid Sequence: Mutated DNA Sequence #1: TACATCTTGGCGACT What's the mRNA sequence? (Circle the change) AUG TALAALLA What will be the amino acid sequence? Will there likely be effects?_ What kind of mutation is this? Mutated DNA Sequence 12: TACGAC CTTGGCGACT What's the mRNA sequence? (Circle the change)...
Of the following genetic variants (deletion, missense, nonsense, and splice site mutations), which types of these mutations will be detected by comparative RNA hybridization and/or comparative genomic hybridization and explain why?
Which of the following statements regarding gene mutations is NOT true? Conditional mutations have different phenotypic effects under different conditions and can be used to study the function of essential genes. Silent mutations cannot have any phenotypic effect on an organism. Frameshift mutations often result in a truncated protein product, similar to a nonsense mutation. Dominant mutations have a phenotypic effect despite the presence of one functional wild type allele.