What is the mutation that causes sickle cell disease? Is it a missense or nonsense mutation?...
What is the mutation that causes sickle cell disease? Is it a missense or nonsense mutation? Is it a transition or a transversion? What is the inheritance pattern of the disease? What population has a high number of heterozygotes?
Homework Answers
Answer:
Substitution mutation that causes sickle cell disease. One nucleotide (A) is replaced by another nucleotide (T), which caused to change glutamic acid to valine. So it is called a missense mutation. Nucleotide adenine (purine) is replaced by thymine (pyrimidine). So it is called transversion mutation.
Normal DNA-----GAG
Mutated DNA---GTG
Normal AA-----Glutamic acid
Mutated AA--Valine.
This is an autosome linked recessive trait that is transmitted from the parent to the offspring when both the partners are carriers for the gene (heterozygous). It is a metabolic disorder characterized by a decreased oxygen transport in the blood. The decrease is due to the presence of defective haemoglobin (HbS) in place of normal haemoglobin (Hb). HbS has low affinity for oxygen and the RBC becomes sickle shaped with pointed edges
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What is the mutation that causes sickle cell disease? Is it a
missense or nonsense mutation?...
please help 6. How can a missense mutation-such as in sickle cell disease-result in a protein...
please help
6. How can a missense mutation-such as in sickle cell disease-result in a protein that has an abnormal structure? Some of these mutations are lethal or cause serious disease, such as cystic fibrosis and sickle cell disease. Many of these point mutations that cause genetic disorders occur as a result of errors in DNA replication or crossing over. 7. What will be the consequence if a single base is deleted from the coding region of a gene?
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele,...
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, though, in areas with a high rate of malaria, heterozygotes that carry the sickle cell allele have a higher fitness than do individuals that are...
In a form of early-onset Alzheimer disease caused by a mutation on chromosome 14,
In a form of early-onset Alzheimer disease caused by a mutation on chromosome 14, A is changed to T at the first position of codon 146, which substitutes leucine for methionine. This mutation is a _______ and is _______ Select one: a. Transition; missense b. Transversion; nonsense c. Transversion; missense d. Transition; nonsense
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion,...
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion, Frameshift mutation Label these genetic changes (a-e). More than one answer may apply to each answer. a. GC->CG in the protein coding region on a gene. b. GC->TA in a GAA glutamate codon c. Loss of three bases GAA for a glutamate codon d. GC->CG in a tRNA gene e. GC->AT in the ribosome binding site of a mRNA
mutation: sickle cell Explain in terms of the listed mutation and structural elements, what causes polymerization...
mutation: sickle cell
Explain in terms of the listed mutation and structural elements, what causes polymerization of hemoglobin. Explain how polymerization of hemoglobin causes sickled cells.
What kind of mutation does the Glu to Val mutation represent? Explain your answer for each....
What kind of mutation does the Glu to Val mutation represent? Explain your answer for each. Silent vs. Missense vs. Nonsense Gain of function vs. Loss of function Transversion vs. transition
What kind of mutation does the Glu to Val mutation represent? Explain your answer for each....
What kind of mutation does the Glu to Val mutation represent? Explain your answer for each. Silent vs. Missense vs. Nonsense Gain of function vs. Loss of function Transversion vs. transition
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele,...
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, in areas with high rates of malaria, a single Sallele confers some resistance to malarial infection. Suppose there is a population with the observed and...
Use the following information to answer the next two questions. Sickle cell anemia is a disease...
Use the following information to answer the next two questions. Sickle cell anemia is a disease that is caused by a mutation in the gene that produces haemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces haemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell...
What type of physical mutation is least likely to affect gene function? A nonsense B missense...
What type of physical mutation is least likely to affect gene function? A nonsense B missense - nonsynomous C missense - synomous D silent E polymorphism F frameshift
please help
6. How can a missense mutation-such as in sickle cell disease-result in a protein that has an abnormal structure? Some of these mutations are lethal or cause serious disease, such as cystic fibrosis and sickle cell disease. Many of these point mutations that cause genetic disorders occur as a result of errors in DNA replication or crossing over. 7. What will be the consequence if a single base is deleted from the coding region of a gene?
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, though, in areas with a high rate of malaria, heterozygotes that carry the sickle cell allele have a higher fitness than do individuals that are...
mutation: sickle cell
Explain in terms of the listed mutation and structural elements, what causes polymerization of hemoglobin. Explain how polymerization of hemoglobin causes sickled cells.
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, in areas with high rates of malaria, a single Sallele confers some resistance to malarial infection. Suppose there is a population with the observed and...
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