Question

Draw all steps in one round of fatty acid biosynthesis, starting with a malonyl-ACP and an acetyl-ACP. Show all atoms of each compound and where energy is involved. You don’t need to name the compounds, but do provide the ‘last name’ each enzyme. Next to each enzyme name, write the name of the Krebs cycle enzyme that is most directly opposite in function.

Answer 1

Date....... 0 Fatty acid synthesis - O 요 1 CH₂-c-SCOA + H-sacp Acetyl-CoA Acetyl con ACP Ibansaylase H-COAR CH₃-C-SACP Acetyl-ACP fi 0 CO2 + * CH2 - C -SCOA + H2S ACP Malohyl-CoA sy MalonyL COAACP H-SCOA of tranacylose CH₂-C-GACP Malonyl-ACP CO2 . 유 1 CH₂ - C-SACP & SACE HyC-Clasne स Hye-&-ch--SACE Coat Hose Acetoacetyl - ACP Spiral

2 Date..... 유 q ① 4C - C- CH₂ - C-SACP Acetoacetyl - ALL TEENADPHE IB-keto acyl-ACP reductase NADPL on M₂-C CHQ- C -SACP ů 9-p-Hydroxy bytyy- ACP OH 9 BHC - G - CH₂ - C - SACP on p-Hydroxy buty syl-Ace 6- Hydroxyacyl-Acf deryabase Hoel C-C-SACP CH, C-C-SACP L-B-trans - Butenoy 1 - ACP - SAC -Ć --C-SACP hi 8 CH₂ and toay Butenoj) - ACP Altinhonig lenoyl - Acp_reductaye NAOP * A Cthy - CH₂ - CH₂ - C -SACP Buty sy| ACP ozu Spiral

3 Date...... 6 CH - CH₂ - CH₂ - C-SACO la Butyry I-ACP T t La Recycle R 2-6 six More timed T i Cliz -CH2-(C142 343 -Ć-SACP Palmitoyl-ACP 13 CH₂ - CH₂ - (CH) C-SACP Palmitoyl - Ace Ho Palmitoyl thioesterase CH, CP₂ - (CH2) 13 с + H-SACP Palmitate Fatty Acid sythesis complete All enzynies that present in Patty Acid synthesia. O Trans Acylove is Acetylco:A Brunoxlares Acetyl-Ace Malony ICO-A Reductase --> Aceto acytyl-Ace Reductane Oaß-Hydroxybutyry/- 2 Tansacy lose Deryacglase, malony I-ACP ACP Spiral

Date.. (4 B-Hydroxy acy LACP olehydbase 30-B- Hydəoxy, butyryl-Ace (B-Hyelroxy Acyl-Ace Adeholrase engre 2-ß - Hang- pytenoyl-ACP Enoyl-Ace Reductase - 8 trany - Butchoy 1- ACP Enel-ACP Reductase Butyryl-Ace Pollwitoy) theioaceterose: palmitoyl Ace palmitoy theoaceterose Palmitate These all engines are present in fatty Acid synthetto * Acetyl-COA Buzrue id common in Fatty Acid synthesid and keep cycle. in krep cycle sotty Acetyl, co a formed the "oxaloacetate, but in fatty Acid Syntheir Acetyl-CoA personied the Acetyl ACP.