Why do normal T cells, which recognize foreign peptide antigens bound to self MHC molecules, react...
- Why do normal T cells, which recognize foreign peptide antigens bound to self MHC molecules, react strongly against the allogeneic MHC molecules of a graft?
Homework Answers
Allogeneic MHC molecules with any bound peptide are probably going to resemble self MHC plus a foreign peptide, hence normal T cells might cross-react with the allogeneic molecules. There are thousands of copies of allogeneic MHC molecules on every graft cell showing different donor peptides. Several of these peptide-MHC complexes may be recognized by one of the many thousands of clones of a graft recipient's T cells. Individuals develop tolerance to self-antigens but do not tolerate the foreign antigens of a graft.
Add Answer to:
Why do normal T cells, which recognize foreign peptide antigens
bound to self MHC molecules, react...
A) T cells B) B cells 18. Helper T cells recognize. 19. These cells recognize cells...
A) T cells B) B cells 18. Helper T cells recognize. 19. These cells recognize cells that contain foreign antigens (virally infected cells, tumor cells, foreign tissue grafts). 20. Cytotoxic T cells recognize. 21. TAP transporter transports peptides that are loaded onto. 22. These cells recognize whole protein antigens C) MHC I molecules D) MHC II molecules
Which of the following statements about how B and T cells recognize antigen are true? Correct...
Which of the following statements about how B and T cells recognize antigen are true? Correct any false statements. a. B cells only recognize antigen presented by class I or class II MHC molecules. b. Both cell types can recognize extra-cellular antigen free-floating in solution. c. Both cell types recognize extracellular matrix-bound antigens. d. T cells only recognize antigen presented by class I or class II MHC molecules.
31. Which part of this T cell receptor is produced only AFTER the T cell has...
31. Which part of this T cell receptor is produced only AFTER the T cell has bound an antigen? A. The part labeled "A" B. The parts labeled "B" C. The entire T cell receptor D. None of it. It is all produced BEFORE antigen binding. E. T cells don't bind antigens; only antibodies do that. 37. How do Treg cells differ from Th cells? A. When Treg cells bind B7, they engulf and destroy it. B. Treg cells secrete...
PLEASE PUT A REFERENCE. THANKS. Consider a naive T cell that expresses a T cell receptor that has specificity for a self...
PLEASE PUT A REFERENCE. THANKS. Consider a naive T cell that expresses a T cell receptor that has specificity for a self peptide bound to MHC and a naive B cell that expresses a B cell receptor which binds a self protein with high affinity. What natural mechanisms exist that prevent the activation of these cells when they encounter self antigens?
which one is correct answer? QUESTION 15 Why are thymocytes with very low interactive avidity with...
which one is correct answer?
QUESTION 15 Why are thymocytes with very low interactive avidity with self-MHC of no potential value?. O a. T cells do not need MHC molecules to recognize antigen O b. No recognition of self can lead to autoimmune disease. O c. T cells must recognize self MHC in order to recognize antigen O d. None of the above
Adaptive Immunity: Second Line of Defense—Cellular Defenses The T-cell receptors and CD4 and CD8 molecules interact...
Adaptive Immunity: Second Line of Defense—Cellular Defenses The T-cell receptors and CD4 and CD8 molecules interact with major histocompatibility complex (MHC) proteins. MHC proteins are found on most cells of the body. There are two variations, or classes, of MHC proteins. MHC class I is expressed on the surface of most cells of the body such as skin cells, liver cells, and others. Should a cell become infected with a virus, viral antigens are processed in the cells and expressed...
Which of the following statements is (are) true of a T cell that expresses two α chains (and thus...
Which of the following statements is (are) true of a T cell that expresses two α chains (and thus two different T-cell receptors) as a result of ineffective allelic exclusion of the α chain during rearrangement? There will be two unique TCRs on the surface of this T cell. Engaging either of the T-cell receptors on MHC molecules of the thymic epithelium will result in positive selection. If either T-cell receptor binds strongly to self-peptide presented by self-MHC molecules, the...
ANSWER ALL QUESTIONS FULLY AND CORRECTLY 5-1 T cells recognize antigen when the antigen a. forms...
ANSWER ALL QUESTIONS FULLY AND CORRECTLY
5-1 T cells recognize antigen when the antigen a. forms a complex with membrane-bound MHC molecules on another host-derived cell b. is internalized by T cells via phagocytosis and subsequently binds to T-cell receptors in the endoplasmic reticulum c. is presented on the surface of a B cell on membrane-bound immunoglobulins d. forms a complex with membrane-bound MHC molecules on the T cell e. bears epitopes derived from proteins, carbohydrates, and lipids. 5-2 a....
Help, please. Which statements are true? Explain why or why not. 24-1 Tcells whose receptors strongly...
Help, please.
Which statements are true? Explain why or why not. 24-1 Tcells whose receptors strongly bind a self-pep- tide-MHC complex are killed off in peripheral lymphoid organs when they encounter the self peptide on an anti gen-presenting dendritic cell 24-2 To guarantee that the antigen-presenting cells in the thymus will display a complete repertoire of self pep- tides to allow elimination of self-reactive T cells, the thy mus recruits dendritic cells from all over the body 24-3 The antibody...
Phagocytosis of aged, damaged, or otherwise unwanted cells makes use of PRRs that recognize: Damage-associated...
Phagocytosis of aged, damaged, or otherwise unwanted cells makes use of PRRs that recognize: Damage-associated molecular patterns Pathogen-associated molecular patterns Peptidoglycan Double-stranded RNA All of the above Which of the following statements about phagocytosis is FALSE? Phagocytes move toward an area of infection by a process called chemotaxis The phagolysosome is a vacuole in which bacteria are exposed to degradative enzymes Phagocytes have receptors that recognize complement proteins bound to bacteria Phagocytes do NOT have receptors that recognize bacteria...
A) T cells B) B cells 18. Helper T cells recognize. 19. These cells recognize cells that contain foreign antigens (virally infected cells, tumor cells, foreign tissue grafts). 20. Cytotoxic T cells recognize. 21. TAP transporter transports peptides that are loaded onto. 22. These cells recognize whole protein antigens C) MHC I molecules D) MHC II molecules
31. Which part of this T cell receptor is produced only AFTER the T cell has bound an antigen? A. The part labeled "A" B. The parts labeled "B" C. The entire T cell receptor D. None of it. It is all produced BEFORE antigen binding. E. T cells don't bind antigens; only antibodies do that. 37. How do Treg cells differ from Th cells? A. When Treg cells bind B7, they engulf and destroy it. B. Treg cells secrete...
which one is correct answer?
QUESTION 15 Why are thymocytes with very low interactive avidity with self-MHC of no potential value?. O a. T cells do not need MHC molecules to recognize antigen O b. No recognition of self can lead to autoimmune disease. O c. T cells must recognize self MHC in order to recognize antigen O d. None of the above
ANSWER ALL QUESTIONS FULLY AND CORRECTLY
5-1 T cells recognize antigen when the antigen a. forms a complex with membrane-bound MHC molecules on another host-derived cell b. is internalized by T cells via phagocytosis and subsequently binds to T-cell receptors in the endoplasmic reticulum c. is presented on the surface of a B cell on membrane-bound immunoglobulins d. forms a complex with membrane-bound MHC molecules on the T cell e. bears epitopes derived from proteins, carbohydrates, and lipids. 5-2 a....
Help, please.
Which statements are true? Explain why or why not. 24-1 Tcells whose receptors strongly bind a self-pep- tide-MHC complex are killed off in peripheral lymphoid organs when they encounter the self peptide on an anti gen-presenting dendritic cell 24-2 To guarantee that the antigen-presenting cells in the thymus will display a complete repertoire of self pep- tides to allow elimination of self-reactive T cells, the thy mus recruits dendritic cells from all over the body 24-3 The antibody...
Most questions answered within 3 hours.
-
The mean waiting time at the drive-through of a fast-food
restaurant from the time an order...
asked 4 minutes ago -
The pitch (p) of a helix is defined as p = dn, in which n is...
asked 6 minutes ago -
Do you agree that the declining stock of social capital is the
blame for the failure...
asked 10 minutes ago -
A researcher is interested in whether coffee consumption helps
with performance on reading comprehension tasks. The...
asked 20 minutes ago -
it has been estimated since the beginning of the human race that
about 133 metric ton...
asked 25 minutes ago -
Where must Medicare prescription drug plans allow for
participants to fill their prescriptions?
asked 28 minutes ago -
Five moles of monatomic ideal gas have initial pressure 2.50 ×
103 Pa and initial volume...
asked 43 minutes ago -
A resistor and the capacitor are used to control the timing in
the RC circuit of...
asked 43 minutes ago -
Living in a group could bring several disadvantages to an
individual. What are some of the...
asked 1 hour ago -
Complete and balance the following reactions. In case of no
reaction occurring write NR.
Mix #1:...
asked 1 hour ago -
If an economy consumes 75% of any increase in income, then an
increase in autonomous investment...
asked 1 hour ago -
A shotputter throws the shot with an initial speed of 15.8 m/s
at a 38.0 ∘...
asked 1 hour ago