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22. In the pedigree shown below it has been found that the disease (indicated by the filled circles) is caused by a RARE auto

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22) In the given Pedigree chart the disease is caused by autosomal recessive mutation with paternal imprinting. The individual I-2 is affected. So, the genotype of 1-2 must be aa*. The individual II-4 is not affected by the disease. So, the individual must be heterozygous for the allele (Aa). The paternal imprinting is represented by Aa*. So, the answer for this question is option C (aa* and Aa*).

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