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name two classesof chemotherapeutics that inhibit cellular metabolism and outline how each drug inhibits cell growth

name two classesof chemotherapeutics that inhibit cellular metabolism and outline how each drug inhibits cell growth
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Answer- The name of two classses of chemotherapeutics are as follows:

1. Mitotic inhibitor- It binds to the tubulin and destabilizes microtubule and causes mitotic arrest in metaphase state in cell and thus inhibit cell growth. Example- Vincristine, Vinblastine

2. Topoisomerase inhibitor- It will inhibit topoisomerase enzyme and thus double helical DNA strands are not separated for replication. Example- Topotecan

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