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Triglycerides can be broken down by hydrolysis reactions to glycerol and fatty acid chains in the...

  1. Triglycerides can be broken down by hydrolysis reactions to glycerol and fatty acid chains in the digestive tract. Glycerol is easily converted to 1 phosphoglyceraldehyde also known as PGAL. Using your knowledge about how aerobic cellular respiration functions, explain how from this original glycerol molecule how many ATP’s are formed in this process. Make sure you include explanations where each ATP is made.
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1. Glycerols are oxidized into dihydroxyacetone phosphate which is isomerized into glyceraldehyde 3 phosphate and enters glycolysis.
One NADH is formed during this oxidation.

2. In glycolysis, two ATP and one NADH is formed by one molecule of glyceraldehyde 3 phosphate.
The resultant one pyruvate enters Kreb's cycle in the form of acetyl CoA. Link reaction forms one NADH and is catalyzed by pyruvate dehydrogenase.

3. In Kreb's cycle, acetyl CoA is oxidized into CO2 and H2O with the formation of a total of 3 NADH and one FADH2 and one ATP.
So, a total 3 ATPs are obtained from substrate-level phosphorylation so far.
Total NADH= 1 NADH from oxidation of glycerol + one NADH from glycolysis + one NADH from link reaction + 3 NADH from Kreb cycle = 6 NADH.

4. Oxidation phosphorylation of 6 NADH and one FADH2 obtains a total of 6x3= 18 ATP from NADH and 2 ATP from FADH2.
This makes a total 20 ATP from oxidative phosphorylation and 3 ATPs from substrate-level phosphorylation.

One glycerol = 23 ATP

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