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If mRNA is mispliced and what was once an intron now becomes coding sequence, what may...

If mRNA is mispliced and what was once an intron now becomes coding sequence, what may happen?

A. Will always have frameshift that will cause the appearance of new stop codons. B. New coding sequence could be spliced in-frame, could result in new amino acids and proteins C. Misplicing of mRNA can never occur D. None Above

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Answer #1

Answer: Option A is correct.
Description:
When there is a mistake during splicing or if there is a mutation in the splicing machinery or at the splice site junction, splicing will not be proper. It would lead to the retention of introns or skipping of exons.
The retention of introns most often leads to the production of truncated proteins due to the appearance of an in-frame stop codon.

Sometimes, although rare, intron retention may result in the production of a different protein sequence. These proteins are often non-functional or they may exhibit gain-of-function phenotypes.

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