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Extensive use of a certain drug leads to addiction, children from matings between mothers and non...

Extensive use of a certain drug leads to addiction, children from matings between mothers and non addicted fathers are addicted while those from reciprocal matings are non-addicted. The reciprocal cross differences are not due to cytoplasmic genes, offer an explanation to account for these result

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During fertilization, apart from the genetic material in the nuclei from each parent, there is a transfer of maternal mitochondria to the foetus. The mitochondrial DNA can account for the differential addiction rate depending on the expression of mitochondrial gene. Since only the maternal mitochondrial DNA is transferred, the reciprocal cross is non addicted.

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