Which type of gene is an HDAC inhibitor most likely to activate: one with trimethylated histone...
Which type of gene is an HDAC inhibitor most likely to activate: one with trimethylated histone H3K4 or trimethylated histone H3K9?
Homework Answers
Answer=Trimethylated H3K4
Explanation-
Histone H3K9 possess an inhibitory signal which going to recruits Histone deacetylase (HDAC) so gene expression inhibited.
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Which type of gene is an HDAC inhibitor most likely to activate:
one with trimethylated histone...
For a given gene mutation reserchers have noticed that histone deacetylase (HDAC) is beneficial in vitro....
For a given gene mutation reserchers have noticed that histone deacetylase (HDAC) is beneficial in vitro. 1. What method would you utilize to determine gene mutation is loss of function or toxic gain of function? 2. Based on HDAC eveidence would you expect loss of function or toxic gain of function? 3. What approach(es) would be a viable molecular therapy? How would the approach mediate the effect? 4. How would you determine whether the effect is cell type specific?
What does trimethylation of H3K4 generally do to gene expression? Activate, increasing transcription of the associated...
What does trimethylation of H3K4 generally do to gene expression? Activate, increasing transcription of the associated gene Nothing-this does not affect the DNA, only histone conformation Repress, decreasing transcription of the associated gene
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to...
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to either transcriptional activation or repression. How do you suppose that the same modification - methylation - can mediate different biological outcomes? Explain what is meant when we say two DNA sequences are 'highly conserved'. Why are some sequences conserved and others aren't? In your own words, explain what is meant by "position effect". What is the molecular basis of this phenomenon?
22. Which of the following events is most likely to give rise to gene families? a....
22. Which of the following events is most likely to give rise to gene families? a. intragenic mutation b. DNA segment shuffling c. gene duplication d. horizontal transfer of DNA e. none of the above
Which is the most inappropriate description of enzyme inhibition? Select one: a. A competitive inhibitor increases...
Which is the most inappropriate description of enzyme inhibition? Select one: a. A competitive inhibitor increases Km only. b. A noncompetitive inhibitor decreases Vmax only. c. An uncompetitive inhibitor decreases both Km and Vmax. d. All of the above e. None of the above
Histone acetylases (HATS) promote gene expression in which of the following ways? They promote the binding...
Histone acetylases (HATS) promote gene expression in which of the following ways? They promote the binding of transcription factors to the DNA They remove a chemical tag from DNA that allows expression to occur They provide a signal for recognition of the start site of the gene They lessen the charge attraction between histones and DNA
10) An inhibitor binds to the allosteric site of an enzyme. What is most likely to...
10) An inhibitor binds to the allosteric site of an enzyme. What is most likely to happen? a. The enzyme will be denatured b. The enyme will be natured C. The products will be created faster d. The rate of reaction will be slowed down 11) Match the organelles with their functions by placing letter (a-d) by each function: a. Ribosomes Package and ship proteins b. Golgi apparatus Store digestive enzymes C. Lysosomes Build proteins with instructions from RNA d....
which one of the following is not characteristic of prokaryotic genomes? a may have have histone...
which one of the following is not characteristic of prokaryotic genomes? a may have have histone like proteins associated in chromatin b) presence of introns c) gene rearranged in operons d) presence of exons e) distinct replication site
If a gene is located in a chromatin region that has high levels of histone acetylation......
If a gene is located in a chromatin region that has high levels of histone acetylation... Select one: a. The gene will have a higher chance of being transcribed as chromatin will be more relaxed (open) b. the gene will be expressed at a higher level because repressors will have a lower chance of binding to the promoter of the gene a c. The gene will be less transcribed because repressors will have a higher chance to bind to the...
Histone de-acetylases prevent further gene expression in which of the following ways? Restoring the charge attraction...
Histone de-acetylases prevent further gene expression in which of the following ways? Restoring the charge attraction between histones and DNA Preventing transcription factor binding Lessening the charge attraction between histones and DNA Adding a chemical tag to the DNA that silences it
What does trimethylation of H3K4 generally do to gene expression? Activate, increasing transcription of the associated gene Nothing-this does not affect the DNA, only histone conformation Repress, decreasing transcription of the associated gene
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to either transcriptional activation or repression. How do you suppose that the same modification - methylation - can mediate different biological outcomes? Explain what is meant when we say two DNA sequences are 'highly conserved'. Why are some sequences conserved and others aren't? In your own words, explain what is meant by "position effect". What is the molecular basis of this phenomenon?
Histone acetylases (HATS) promote gene expression in which of the following ways? They promote the binding of transcription factors to the DNA They remove a chemical tag from DNA that allows expression to occur They provide a signal for recognition of the start site of the gene They lessen the charge attraction between histones and DNA
10) An inhibitor binds to the allosteric site of an enzyme. What is most likely to happen? a. The enzyme will be denatured b. The enyme will be natured C. The products will be created faster d. The rate of reaction will be slowed down 11) Match the organelles with their functions by placing letter (a-d) by each function: a. Ribosomes Package and ship proteins b. Golgi apparatus Store digestive enzymes C. Lysosomes Build proteins with instructions from RNA d....
If a gene is located in a chromatin region that has high levels of histone acetylation... Select one: a. The gene will have a higher chance of being transcribed as chromatin will be more relaxed (open) b. the gene will be expressed at a higher level because repressors will have a lower chance of binding to the promoter of the gene a c. The gene will be less transcribed because repressors will have a higher chance to bind to the...
Histone de-acetylases prevent further gene expression in which of the following ways? Restoring the charge attraction between histones and DNA Preventing transcription factor binding Lessening the charge attraction between histones and DNA Adding a chemical tag to the DNA that silences it
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