What is involved in making a human growth hormone in the milk of a livestock? Compared...
What is involved in making a human growth hormone in the milk of a livestock? Compared with the production of proteins by bacteria, why might it be more advantageous?
Homework Answers
Production of human growth hormone in the milk of livestock involves the genetic engineering approach of cloning the gene responsible for the production of growth hormone (if it is a single gene) or cloning of all the genes involved in the pathway for synthesis of human growth hormone. The cloning can be done at the embryonic stage so that the probability for gene incorporation and activation will be high.
Compared with the production of proteins using bacteria, it might be more advantageous as the production of growth hormones require post-translation modification. Hence, a eukaryotic system is advantageous over a prokaryotic system as the proteins produced by prokaryotes lack post-translational modification. Moreover, if cloning of more than one gene is required then a prokaryotic system might not be able to handle the large size of a gene.
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What is involved in making a human growth hormone in the milk of
a livestock? Compared...
we transform bacteria to make medically useful human proteins such as insulin and growth hormone. explain...
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Only information given Explain how you might engineer E. coli to produce human growth hormone (HGH)...
Only information given
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Scientists have engineered bacteria to produce human proteins such as human growth hormone (hGH) to help treat dwarfism. Suppose the unmodified eukaryotic gene coding for hGH is inserted directly into a bacterial chromosome. Select the reasons why no expression would be seen in the bacterial cell for the hGH gene. Bacteria cannot remove intronic sequence from a gene, so if the gene for hGH were transcribed, it would translate to a nonfunctional protein. The bacterial nucleoid does not have the...
Only information given
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why might it be advantageous for bacteria to prevent
transcription of a particular enzyme unless it’s substrate is
present in the enviroment
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