What is the ApoE gene and which genotypes are associated with a higher disease risk for CVD and Alzheimer's?
The APOE gene provides instructions for making a protein called apolipoprotein E.This protein combines with fats(lipids) in the body to form molecules called lipoproteins.Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream.Maintaining normal levels of cholesterol is essential for the prevention of disorders that affect the heart and blood vessesls(cardiovascular diseases), including heart attack and stroke.
APOE e3 is associated with higher risk of Cardiovascular diseaseand APOE e4 is associated with Alzheimer's disease.
What is the ApoE gene and which genotypes are associated with a higher disease risk for...
One allele of the APOE gene is associated with early Alzheimer’s disease, while another allele appears to help prevent Alzheimer’s. In a brain cell of an individual with the first type of allele, we find high levels of the protein. In the brain cell of an individual with the second allele, we find no protein. This indicates the mutation may be found in: A. an intron in the gene B. the stop codon C. the 3' UTR D. the promoter...
You're studying genotypes at a gene that you've discovered contributes to shoulder inflammatory disease. The gene has two alleles: Q and q. QQ homozygotes produce, on average, 2.2 kids. Qq heterozygotes also produce, on average, 2.2 kids. However, qq homozygotes are more likely to have the disease, and therefore, produce, on average, 1.7 kids. What is the relative fitness of the qq genotype? show your work
Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene? Given that is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without...
You are studyingHuntington's disease. You would like to identify
the gene associated with huntington's, and so you look at the SNP
profile of a large family with Huntington's. Below are the results
The color box indicates the disease, while the elements below the
box describe the SNPS.
a) Which SNPs are linked to the Huntington's disease gene? How
did you know?
b) What is the orientation of the alleles in the FAther, and
what is map distance between the SNP...
1. List the major risk factors for coronary heart disease and indicate which ones are modifiable and which ones are not 2. Review Table 27-3 Lifestyle Management to Reduce CVD Risk (TLC Diet Guidelines) (Pages 380-384 (Original pages 800-804)), the DASH Eating Plan (Pages 391-393 (Original pages 811-813)), and Table 27-5. Read each section in the chapter for specific guidelines on each diet. As the chapter describes, the DASH dietary pattern is helpful for lowering blood pressure and for reducing...
QUESTION 7 In a clinical study, volunteers are tested for a gene that has been found to increase the risk for a disease. The probability that a person carries the gene is 0.1. Ten people are tested what is the probability that 3 or more people are found to have the gene?a. Approx. 7.0296 b. Approx. 92.98% c. Approx. 98.72% d. None of the above QUESTION 8 In a clinical study, volunteers are tested for a gene that has been found to increase the risk for...
Incidence and prevalence rates can also be used to compare the rates of disease across different settings (places), people, or time. We therefore need measures of comparison. The ratio of two measures of disease frequency is called the relative risk. The difference between two measures of disease frequency is called the risk difference, or rate difference. In some cases, it involves a measure in an exposed group (or groups) and a measure in an unexposed or comparison group. In other...
Please explain in laymans term :( Background and aim: Hypertensive pregnancy disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown.Weaimed to evaluatewhether hypertensive pregnancy disorder in first pregnancy is associated with increased subsequent risk of maternal CVD after adjustment for established CVD risk factors measured after pregnancy. Methods and results: A total of 20,075 women with a first delivery registered in the Medical Birth Registry of...
Food groups associated with a decreased risk of chronic disease
Agnes has recently been diagnosed with Alzheimer's Disease, a degenerative brain disease, associated with memory loss. Agnes is living alone at home, has recently experienced significant weight loss, and frequently forgets when her last meal was, of if she ate at all. When speaking with you, she ensures you that she had breakfast this morning, but her daughter, Marie, insists that she is forgetting to eat and may be at risk for malnutrition. What are two suggestions you could provide...