Example | Target | Mechanism |
Penicillin | target cell wall | inhibits the formation of peptidoglycan cell wall in bacteria by blocking the synthesis of Tetra peptide linkage which links adjacent sugar molecules |
Rifampicin | target RNA synthesis | inhibits DNA dependent RNA synthesis in bacteria by blocking the activity of DNA dependent RNA polymerase |
Tetracycline | target ribosomes | inhibits the initiation of translation in bacteria by binding to smaller subunit of ribosome (30S) |
Chloramphenicol | target ribosome | Inhibits protein elongation in bacteria by preventing the activity of peptidyl transferase enzyme |
Ciprofloxacin | targets DNA synthesis | It blocks DNA synthesis by blocking the activity of DNA gyrase and type 2 topoisomerase enzyme |
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Describe five different ways by which antibiotics can disrupt bacterial cells and cell growth. Give an...
54. Describe three targets of antibiotics in bacterial cells. Which target provides the optimal therapeutic index? How do bacteria become resistant to antibiotics?
2. Research how antibiotics affect bacterial cells. Which cell structure(s) are typically targeted? Based on this information do you think human cells are affected by the antibiotics? Include references to information sources used. 3. As mentioned in the introduction, both humans and fungi are eukaryotic. Looking at the structures found in human and fungal cells, propose one possible cellular target that would impact fungal cells but not human cells.
Chapter 12 Study Guide 1. What are the bacterial cell targets of the different antibiotics? 2. Define the following terms: a. Antibiotic resistance b. Antibiotic sensitivity c. Broad-spectrum antibiotic d. Narrow-spectrum antibiotic e. Semisynthetic antibiotic 3. Describe the mechanism of action (target) for the following antibiotics: a. Penicillins (including semisynthetics) b. Cephalosporins c. Quinolones and Fluoroquinolones d. Bacitracin e. Vancomycin f. Carbapenems g. Tetracyclines h. Sulfonamides i. Polymyxin B j. Aminoglycosides k. Macrolides I. Chloramphenicol m. Oxazolidones n. Isoniazid o....
Antibiotics should inhibit bacterial cell growth without generating side effects in the human patient, but that is not always the case. Some antibiotics that inhibit bacterial protein synthesis by binding to bacterial ribosomes induce negative side effects in patients. What is the most likely cause of these side effects? Choose one: A. The antibiotics interfere with mitochondrial ribosomes. B. The antibiotics interfere with ribosomes attached to the ER, impairing RER function. C. The antibiotics interfere with cytoplasmic ribosomes. D. The...
List, and briefly discuss, (1-2 sentences max for each) the THREE different ways bacterial cells can exchange genetic information.
cuse u grunt pleyenire bullial cell 3) Suppose that you place some bacterial cells on an LB agar plate containing ampicillin. One of these bacterial cells is resistant to ampicillin; the other bacterial cells are not resistant to ampicillin (see far left plate on the picture below). After incubating the plate for 24 hours, only the ampicillin-resistant cell is able to form a colony. However, if the plate is incubated for an additional 48 hours, the other nearby bacterial cells...
Select ways in which genomic instability can arise. over proliferation of cells bacterial infections changes in chromosome structure changes in chromosome number mutations in DNA-repair genes Select ways in which genomic instability can arise. over proliferation of cells bacterial infections changes in chromosome structure changes in chromosome number mutations in DNA-repair genes
List and describe chemical agents used in control of Explain three ways how pathogenic microbes cause diseases in their hosts. What are the main stages in the course of infection and disease? Explain the main events and characteristics for each of these stages. Explain the role of reservoirs and vectors in maintenance and spreading of infectious agents. What is the difference between mechanical and biological vectors? What are carriers? Explain endemic and sporadic diseases. What are epidemic and pandemic diseases?...
The bactericidal antibiotic penicillin kills bacterial cells by preventing peptidoglycan (cell wall) biosynthesis. Which of the following phases of the bacterial growth curve would you expect penicillin to be most active against?
12a. If you plated transformed cells on LB, what would the growth look like? Why? b. How else could growth occur on plates with both antibiotics with regard to “successful” transformation? (Hint: How else could you both genes “get into” bacterial cells?) c. What other ways can growth occur on plates with both antibiotics () that do not have anything to do with transformation/molecular cloning?