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what are the mechanisms that streptococcus pneumoniae utilize to cause disease in the nervous system?

what are the mechanisms that streptococcus pneumoniae utilize to cause disease in the nervous system?
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Streptococcus pneumoniae damages the local tissue or transcytose the infected leukocytes to reach the CNS by breaking the blood-brain barrier. a toxin called pneumolysin is produced by the bacteria when it damages the blood brain barrier and causes meningitis.

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