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how does strong selection occuring in a population impact the molecular clock

how does strong selection occuring in a population impact the molecular clock
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A 1986 study concluded that selection is a legitimate reasoning for protein evolution. With strong selection there might be mutations that get introduced into the population. The main use of molecular clock is to estimate evolutionary timescales. In general the molecular clock hypothesis states that the rate of change of the DNA and thus protein sequences is relatively constant with respect to time in different organism. Now, if the selection is strong, a distinct change or variation will be observed in the DNA and proteins of the population at different time frames. So, now, the molecular clock will not be relatively constant with time as it originally states.

If the time scale of the change of the tick rate of the molecular clock is assumed to be much less than the average time between substitutions, then it is shown that the substitution process must be episodic, with bursts of substitutions being separated by long periods of time with no substitutions

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