One antibiotic that has been recently developed blocks the association of the small and large subunits...
One antibiotic that has been recently developed blocks the association of the small and large subunits of the ribosomes at the beginning of translation. Which site in the ribosome do you think binds the antibiotic so the association of the small and large subunits is blocked?
A site
G site
P site
E site
Homework Answers
The correct option is E site.
Initiation factor (specifically IF-3) binds to the small subunit and blocks it from re-associating with a large subunit. This occurs during the initiation of translation. By understanding this step, it can be assumed that the developed antibiotic binds to the E site, which is the primary site for the association of the small and large subunits of the ribosome. This site is regulated by factors (such as IF3). This antibiotic may act as a homolog to the IF3, hence binding to the E site during the initiation of translation and preventing the association of the small and large subunits.
A site cannot be the correct option because this site does not play a role in the association of the subunits of the ribosome. The A site is the binding site for the amino-acylated tRNA.
P site cannot be the correct option since this site is also not associated with the association of the subunits of the ribosome. The P site is the binding site for the peptidyl-tRNA.
G site is not a site involved in translation
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Answers below
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A patient has been on antibiotic therapy for 1 week and has developed diarrhea as one of the adverse effects. The patient still needs to continue the antibiotic therapy. What drug will the nurse expect to be ordered first? OLoperamide (Imodium AD) Methylcellulose (Citrucel) Diphenoxylate (Lomotil, Lonox) Lactobacillus acidophilus (Lactinex)
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