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Please explain the immune activation for Trypansoma cruzi parasite.

Please explain the immune activation for Trypansoma cruzi parasite.

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Chagas disease is named after the Brazilian physician Carlos Chagas , who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas.

THE IMMUNE ACTIVATION FOR Trypanosoma cruzi parasite basically involves the six different types of methods

1.Complement inactivation of the immune proteins

2.Mammalian nucleated cell phagocyte the parasite and it gets escape into cytosol causing the problem to cell

3.B-cells activation antibodies

4.Delayed immune response of CD8+ T CELLS

5.Macrophages - immunoactivation by TLR2 ,TLR7 , TLR (toll like receptors)

6.Dendritic cells- immunoactivation by TLR 7 and TLR 9

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