PDX-1 must bind to DNA in order to function. A particular arrangement of amino acids with...
PDX-1 must bind to DNA in order to function. A particular arrangement of amino acids with polar r-groups determines the sequence of nitrogenous bases the PDX-1 can bind to via hydrogen bonds; however, a separate binding pocket of the protein helps it attach to the DNA backbone. What would you predict the characteristics of those amino acids are?
Positively Charged
Polar Uncharged
Negatively Charged
Nonpolar
Homework Answers
In nature, substances with like charges repel each other, whereas substances with opposite charges attract each other. DNA has a net negative charge due to the sugar phosphate backbone. Thus, for a protein to bind DNA, it must possess the opposite charge,i.e. should have positive charge. Thus, the binding pocket of the protein PDX-1 that helps it attach to the DNA backbone should be :
| Positively Charged |
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PDX-1 must bind to DNA in order to function. A particular
arrangement of amino acids with...
Question 2 (1 point) Amino acids can be classified as A. Hydrophobic amino acids with nonpolar...
Question 2 (1 point) Amino acids can be classified as A. Hydrophobic amino acids with nonpolar R groups B. Polar amino acids with neutral R groups but the charge is not evenly distributed C. Positively charged amino acids with R groups that have positive charge at physiological pH. D. Negatively charged amino acids with R groups that have a negative charge at physiological pH. How would the amino acid alanine be classified? Think through your reasoning. L-Alanine H2N-CHC-OH CH3
A DNA molecule has many phosphate groups, as shown below What type of amino acid side...
A DNA molecule has many phosphate groups, as shown below What type of amino acid side chains would be most likely be involved in binding this substrate at the active site? Select one polar, negatively charged polar, positively charged hydrophobic polar neutral
Protein Structure A protein contains a string of amino acids (usually more than 50) that has...
Protein Structure A protein contains a string of amino acids (usually more than 50) that has a biological function. 15ecause proteins are so large, their structure has several levels, all of which are important for the proper functioning of the protein. Ultimately, the sequence of amino acids (ordering of polar and nonpolar amino acids) dictates the 3-dimensional shape of a protein and this dictates its primary function. Level 1: Primary (1") The amino acid sequence of a polypeptide Protein Backbone...
36. Which statement is true about Nucleic Acids? a) DNA is a protein b) DNA is...
36. Which statement is true about Nucleic Acids? a) DNA is a protein b) DNA is identical to RNA C) RNA has the structure of a double helix, d) RNA binds to DNA but not to amino acids. e) None of these are true. 37. Which is true for DNA, RNA and Polypeptides? a) They all have R groups, b) They are formed from ribose by dehydration synthesis. c) They all have subunits that include nitrogenous bases. d) They were...
2. Phosphate groups on the backbone of DNA are negatively charged at neutral pH. This suggests...
2. Phosphate groups on the backbone of DNA are negatively charged at neutral pH. This suggests that DNA-binding proteins are often enriched in which amino acid? A. E B. G C. K D. L E. W 3. You are studying a particular reaction under conditions in which the AG = 12 kJ/mol. Which of the following statements best describes the equilibrium constant (K.) of this reaction? A. Keq < 0 B. Keq = 0 C. 0 < Keq <1 D....
Consider the most common Cystic Fibrosis variant: Wild-type CFTR DNA (Coding-strand): 3 ATC ATC TTT GGT...
Consider the most common Cystic Fibrosis variant: Wild-type CFTR DNA (Coding-strand): 3 ATC ATC TTT GGT GTT atc att ggt gtt... Cystic Fibrosis odi 1. Add the 5' and 3' designations to the DNA. 2. Write the template sequence for the DNA 3. Transcribe the wild-type and CF DNA into mRNA. Be sure to include the 5'/3' labels. 4. Translate the wild-type and CF mRNA into protein. Be sure to label these ends also. 5. In the above wild-type protein,...
c) The steps or rungs of the DNA ladder are composed of phosphate group 4 Deoxyribose...
c) The steps or rungs of the DNA ladder are composed of phosphate group 4 Deoxyribose 15. Use Figure 2 and 3 of the lab to compare the genome of a human with a mouse, fruit fly and yeast. paired in a specific way. d) Adenine in one DNA strand always pain with thymine ) Bases in opposite strands of a DNA molecule are linked together by hydrogen in the other strand and bonds. Yeast Human Mouse Fruit Fly Number...
Question 11. Certain amino acids destabilize or prevent formation of alpha-helices. Which amino acid is more...
Question 11. Certain amino acids destabilize or prevent formation of alpha-helices. Which amino acid is more likely to be found in these structures based on its charge and R-group size? A. Glycine B. Proline C. A sequence of several Glutamate D. A sequence of several Lysine E. Alanine Question 12. Which of the following is least likely to result in protein denaturation? A) Altering net charge by changing pH B) Changing the salt concentration C) Disruption of weak interactions by...
Week 14- Chapter 21 Homework Problem 21.72 < 52 of 58 Review Constants| Periodic Table Part A How does a point mutation for an enzyme affect the order of amino acids in that protein? Drag the term...
Week 14- Chapter 21 Homework Problem 21.72 < 52 of 58 Review Constants| Periodic Table Part A How does a point mutation for an enzyme affect the order of amino acids in that protein? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help then the order of amino acids will change in the of the polypeptide chain If the resulting codon still codes for the same amino acid, If the...
The observation that in any DNA sample, A T and G C A. DNase sequencing An...
The observation that in any DNA sample, A T and G C A. DNase sequencing An analytical method that determines which segments of DNA are bound by a particular B. Chargaff's rule protein factor, such as a transcription factor C. ChIP sequencing D. Euchromatin E. Histone acetylation F. major groove - # Areas associated with a eukaryotic gene that are where most DNA methylation occurs. # An analytical technique that involves a small slide or chip with many segments of...
Question 2 (1 point) Amino acids can be classified as A. Hydrophobic amino acids with nonpolar R groups B. Polar amino acids with neutral R groups but the charge is not evenly distributed C. Positively charged amino acids with R groups that have positive charge at physiological pH. D. Negatively charged amino acids with R groups that have a negative charge at physiological pH. How would the amino acid alanine be classified? Think through your reasoning. L-Alanine H2N-CHC-OH CH3
A DNA molecule has many phosphate groups, as shown below What type of amino acid side chains would be most likely be involved in binding this substrate at the active site? Select one polar, negatively charged polar, positively charged hydrophobic polar neutral
Protein Structure A protein contains a string of amino acids (usually more than 50) that has a biological function. 15ecause proteins are so large, their structure has several levels, all of which are important for the proper functioning of the protein. Ultimately, the sequence of amino acids (ordering of polar and nonpolar amino acids) dictates the 3-dimensional shape of a protein and this dictates its primary function. Level 1: Primary (1") The amino acid sequence of a polypeptide Protein Backbone...
36. Which statement is true about Nucleic Acids? a) DNA is a protein b) DNA is identical to RNA C) RNA has the structure of a double helix, d) RNA binds to DNA but not to amino acids. e) None of these are true. 37. Which is true for DNA, RNA and Polypeptides? a) They all have R groups, b) They are formed from ribose by dehydration synthesis. c) They all have subunits that include nitrogenous bases. d) They were...
2. Phosphate groups on the backbone of DNA are negatively charged at neutral pH. This suggests that DNA-binding proteins are often enriched in which amino acid? A. E B. G C. K D. L E. W 3. You are studying a particular reaction under conditions in which the AG = 12 kJ/mol. Which of the following statements best describes the equilibrium constant (K.) of this reaction? A. Keq < 0 B. Keq = 0 C. 0 < Keq <1 D....
Consider the most common Cystic Fibrosis variant: Wild-type CFTR DNA (Coding-strand): 3 ATC ATC TTT GGT GTT atc att ggt gtt... Cystic Fibrosis odi 1. Add the 5' and 3' designations to the DNA. 2. Write the template sequence for the DNA 3. Transcribe the wild-type and CF DNA into mRNA. Be sure to include the 5'/3' labels. 4. Translate the wild-type and CF mRNA into protein. Be sure to label these ends also. 5. In the above wild-type protein,...
c) The steps or rungs of the DNA ladder are composed of phosphate group 4 Deoxyribose 15. Use Figure 2 and 3 of the lab to compare the genome of a human with a mouse, fruit fly and yeast. paired in a specific way. d) Adenine in one DNA strand always pain with thymine ) Bases in opposite strands of a DNA molecule are linked together by hydrogen in the other strand and bonds. Yeast Human Mouse Fruit Fly Number...
Question 11. Certain amino acids destabilize or prevent formation of alpha-helices. Which amino acid is more likely to be found in these structures based on its charge and R-group size? A. Glycine B. Proline C. A sequence of several Glutamate D. A sequence of several Lysine E. Alanine Question 12. Which of the following is least likely to result in protein denaturation? A) Altering net charge by changing pH B) Changing the salt concentration C) Disruption of weak interactions by...
Week 14- Chapter 21 Homework Problem 21.72 < 52 of 58 Review Constants| Periodic Table Part A How does a point mutation for an enzyme affect the order of amino acids in that protein? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help then the order of amino acids will change in the of the polypeptide chain If the resulting codon still codes for the same amino acid, If the...
The observation that in any DNA sample, A T and G C A. DNase sequencing An analytical method that determines which segments of DNA are bound by a particular B. Chargaff's rule protein factor, such as a transcription factor C. ChIP sequencing D. Euchromatin E. Histone acetylation F. major groove - # Areas associated with a eukaryotic gene that are where most DNA methylation occurs. # An analytical technique that involves a small slide or chip with many segments of...
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