Please tell me the pathway and mechanism of LIMK2 kinases inhibitor
Please tell me the pathway and mechanism of LIMK2 kinases inhibitor
Homework Answers
LIMK2 or LIM kinase 2 are the important protein in the downstream of the signalling pathway and control dynamics of cytoskeleton. Their main function is to control dynamics of microtubules. They are proved to be an important therapeutic target. Therefore, many inhibitors are designed against this therapeutic target. These proteins are involved in the phosphorylation of cofilin protein that depolymerizes actin filaments. The inhibitors include sulfonamide that inhibit the function of LIM kinase 2.
Some survival factors activate receptor tyrosine kinases upstream of the PI-3-kinase-Akt pathway. How does this pathway...
Some survival factors activate receptor tyrosine kinases upstream of the PI-3-kinase-Akt pathway. How does this pathway promote cell survival? Akt phosphorylates and inactivates an inhibitor of Tor. Akt phosphorylates and activates the antiapoptotic protein Bcl. Akt phosphorylates and inactivates the pro-apoptotic proteins Bax/Bak. O Akt phosphorylates and inhibits the Bcl2 inhibitor Bad. In most cases, how many mutations are required for a normal cell to turn into a cancer cell? O more than three O generally only one O cancers...
4) A signaling pathway proceeds through three protein kinases that are sequentially activated by phosphorylation. In...
4) A signaling pathway proceeds through three protein kinases that are sequentially activated by phosphorylation. In one case, the kinases are held in a signaling complex by a scaffold protein. In the other, the kinases are freely diffusing. Discuss the properties of these two types of organization in terms of the signal amplification, speed, and potential cross talk between signaling pathways. (10 Points)
Tell me if the arrowed mechanism is correct. If there is something wrong, please draw out...
Tell me if the arrowed mechanism is correct. If there is
something wrong, please draw out the correct answer instead of
writing it out. It is difficult to comprehend if things are written
in words.
a. NaOEt O mo 30: 0: H* protonation :0: 10:
In feedback inhibition, the inhibitor of the biochemical pathway is Multiple Choice Ο the final product...
In feedback inhibition, the inhibitor of the biochemical pathway is Multiple Choice Ο the final product of the biochemical pathway. Ο a substance that is produced towards the middle of the biochemical pathway. Ο the product of the enzyme inhibited. Ο the substrate of the enzyme inhibited. Ο O a product of another biochemical pathway.
The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme....
The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme. The molecule can adopt either pathway A or B, and can lead to I or II adduct formation. One adduct was formed from 1 covalently linked to pyridoxal 5-phosphate (PLP) (I) while the other adduct was formed with the inhibitor covalently linked to Lysine246, the active site lysine. NH 0 o,po HN н. Lys HN Co.
how thymidine relieve the inhibition of the TTP biosynthetic pathway? and why FUdR inhibitor will be...
how thymidine relieve the inhibition of the TTP biosynthetic pathway? and why FUdR inhibitor will be detected in S-phase? thank you
Phosphatases are a family of enzymes that remove phosphate groups from specific proteins; these phosphate groups had been added to the proteins by protein kinases. Vanadate is an inhibitor of phosphat...
Phosphatases are a family of enzymes that remove phosphate groups from specific proteins; these phosphate groups had been added to the proteins by protein kinases. Vanadate is an inhibitor of phosphatases in eukaryotic cells. What effect would vanadate have on the response of cells to signals received by receptor kinases? A) The signal would still bind the receptor, so there would be no effect. B) The response of the cell would last longer than it normally would. C) The response...
Two protein kinases, K1 and K2, function sequentially in an intracellular signaling pathway. If either kinase...
Two protein kinases, K1 and K2, function sequentially in an intracellular signaling pathway. If either kinase contains a mutation that permanently inactivates its function, no response is seen in the cells when an extracellular signal is received. A different mutation in K1 makes it constitutively active, so that in cells containing that mutation, a response is observed even in the absence of an extracellular signal. You characterize a double-mutant cell that contains K2 with the inactivating mutation and K1 with...
In feedback inhibition of a metabolic pathway, where does the inhibitor bind? Once the substrate moves...
In feedback inhibition of a metabolic pathway, where does the inhibitor bind? Once the substrate moves into active site of the enzyme, What process typically regulates the enzymes involved in metabolic reactions?
Please write and/or draw the calineurin pathway in T-cells AND also the mechanism of calcineurin inhibitors....
Please write and/or draw the calineurin pathway in T-cells AND also the mechanism of calcineurin inhibitors. You can choose to use both words and pictures.
Some survival factors activate receptor tyrosine kinases upstream of the PI-3-kinase-Akt pathway. How does this pathway promote cell survival? Akt phosphorylates and inactivates an inhibitor of Tor. Akt phosphorylates and activates the antiapoptotic protein Bcl. Akt phosphorylates and inactivates the pro-apoptotic proteins Bax/Bak. O Akt phosphorylates and inhibits the Bcl2 inhibitor Bad. In most cases, how many mutations are required for a normal cell to turn into a cancer cell? O more than three O generally only one O cancers...
4) A signaling pathway proceeds through three protein kinases that are sequentially activated by phosphorylation. In one case, the kinases are held in a signaling complex by a scaffold protein. In the other, the kinases are freely diffusing. Discuss the properties of these two types of organization in terms of the signal amplification, speed, and potential cross talk between signaling pathways. (10 Points)
Tell me if the arrowed mechanism is correct. If there is
something wrong, please draw out the correct answer instead of
writing it out. It is difficult to comprehend if things are written
in words.
a. NaOEt O mo 30: 0: H* protonation :0: 10:
In feedback inhibition, the inhibitor of the biochemical pathway is Multiple Choice Ο the final product of the biochemical pathway. Ο a substance that is produced towards the middle of the biochemical pathway. Ο the product of the enzyme inhibited. Ο the substrate of the enzyme inhibited. Ο O a product of another biochemical pathway.
The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme. The molecule can adopt either pathway A or B, and can lead to I or II adduct formation. One adduct was formed from 1 covalently linked to pyridoxal 5-phosphate (PLP) (I) while the other adduct was formed with the inhibitor covalently linked to Lysine246, the active site lysine. NH 0 o,po HN н. Lys HN Co.
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