Iontropic/Transmitter Gated Channels- What are the GENERAL characteristics of these channels? Glutamate-Gated Iontropic Receptors: What are...
1) Which ligand-gated ion channels does (glutamate / GABA / glycine) open? 2) How do changes in (potassium / sodium) concentration affect the resting membrane potential? 3) If (sodium / potassium / chloride) channels are locked open, the membrane potential will continue to change due to ion flow until it reaches what value? (give a numerical value)
Receptors that bind IP3 are generally metabotropic receptors GPCRs receptor tyrosine kinases ligand-gated ion channels
The opening of metabotropic G-protein-coupled receptor ion channels is faster than ionotropic transmitter-gated ion channels, triggering a wide- spread cellular metabolic effect. True False
Although the ligand-gated ion are ion channels they are considered to be receptors as they only open when bound by which of the following? select two answers please- 1)protein 2)ligands 3)drugs 4)ions 5)sugars
3. Many neurons contain "delayed K channels". Like voltage-gated Nat channels, these voltage-gated K+ channels open in response to a rise in membrane potential and then undergo inactivation. However, opening of the voltage-gated K channels lags behind opening of the voltage-gated Na channels. a) Why does neuronal function require the voltage-gated K channels to open more slowly than the voltage-gated Na channels? b) Compared to a neuron that lacks voltage-gated K channels, what differences would you expect in the shape...
a. what effect would have the blockade of voltage gated Na+ channels? b. what effect would have the opening of chemically-gated Cl- channels? c. what effect does voltage and chemically gated have in common? d. what final effect do you expect to see when either local or general anesthetics are administered?
Which of the following statements correctly characterizes synapses? Synaptic vesicles constitute important features for transmission in both chemical and electrical synapses A postsynaptic neuron typically receives input from different presynaptic axons that are either excitatory or inhibitory, but it cannot receive inputs from both types Synaptic delay is approximately the same for both chemical and electrical synapses Receptors can provide a gating function with respect to a given ion channel The mechanism of indirect gating of ions normally does not...
what do the ligand gated cation channels do that are located on the sarcolemma? what is the motor end plate? what direction do the ions move? (Na and K) how is the resting membrane potential restored?
You are studying the permeability on Voltage-Gated Sodium Channels involved in action potential generation. Predict what would happen to the permeability of Sodium in the following cases (would it decrease, increase or stay the same?). Explain why you chose your answer. i.Increased receptor number. ii. Add a drug that make channel stay open longer. iii. Raise Vm above+35mV. iv.Lower Vm below -70mV. v.Add a drug that prevents channel opening. vi. Add more Na+ to the extracellular environment.
Assume a mutation of the gene coding for the voltage-gated sodium channel resulted in channels that do not have the ball and chain part of the protein. Which of the following would you expect to see? a. A change in the ion selectivity of the channel of the mutated channels, allowing ions other than sodium to move through it. b. A change in the voltage sensitivity of the channel so that it does not open until more depolarized voltages. c....