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Receptors that bind IP3 are generally metabotropic receptors GPCRs receptor tyrosine kinases ligand-gated ion channels
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D is the correct option.

IP3 binda to its receptor which is located on calcium ion channels of endoplasmic reticulum membarane. When IP3 binds with receptor which caused opening of calcium ion gated channels and calcium ions moves in to cytoplasm from endoplasmic reticulum. Calcium ions activate the so many calcium mediated signal for metabolic reaction.

In case of metabotropic receptors are coupled to the phospholipase C which activate the synthesis of IP3 and DAG.

GPCRs are present on the extracellular domen of ligand receptors like adrenaline. When first messenger bind with GPCR it caused confirmation change and activation of G protein which activate various type of enzyme like adenylate cyclase .

Tyrosine kinase responsible for synthesis of IP3 which bind with IP3 receptor of endoplasmic reticulum.

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