Explain why a glycine residue at position 12 of the G protein Ras is only active...
Explain why a glycine residue at position 12 of the G protein Ras is only active in the presence of growth factors but Ras with an aspartate residue at the same position is oncogenic (can cause cancer).
Homework Answers
Glycine is the normal amino acid residue in Ras at position 12 and is a tightly controlled protein.However aspartate residue at position 12 leads to weak GTP binding and weak GTPase activity, so Ras is not turned off (weak GTP binding has little effect since once GTP binds it is not hydrolyzed). This gain of function is the reason why aspartate at position 12 is oncogenic.
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