Why is acetoacetic ester more acidic than malonic ester?
Design a synthesis(no mechanism) for (Hint: use either a malonic ester or acetoacetic ester synthesis)
The Malonic Acid synthesis is similar to the Acetoacetic Ester synthesis It uses diethyl malonate as the main starting material Draw the structure of diethyl malonate (malonic ester) Diethyl malonate can be hydrolyzed back to malonic acid and if heat is applied after the hydrolysis, will decarboxylate. Draw the mechanism for this transformation starting with malonic acid. Indicate the new C-C bonds in each molecule and then provide the organohalides which were used to synthesize each compound using the malonic...
Prepare any THREE of the following molecules, incorporating either an acetoacetic ester synthesis or a malonic ester synthesis in each synthesis. Show the reagents for each step and the product of each step. Do not draw any mechanisms. CO2Me H2N A B C D
Prepare any THREE of the following molecules, incorporating either an acetoacetic ester synthesis or a malonic ester synthesis in each synthesis. Show the reagents for each step and the product of each step. Do not draw any mechanisms. CO2Me H2N A B C D
6. Using either malonic ester synthesis or acetoacetic ester synthesis, outline a reaction scheme in each case to show how you will synthesize compounds A and B below. [Show all steps with structure of all intermediates and necessary reagents). A. 3-butyl-2-tetradecanone B. 2-propylpentadecanoic acid
Propose an acetoacetic ester synthesis to generate each of thd following ketones: 3. Propose an acetoacetic ester synthesis to generate each of the following ketones:
alon 4) Design a synthetic route that would form the following ketone using Acetoacetic Ester or Malonic Ester Synthesis. You can utilize any aldehyde, ketone, ester alkyl halide, acid, base, and any additional inorganic reagent or solvent needed. Remember to be specific with your choice of reagents and cond itions. Draw out each synthetic step with the reagent(s) needed for performing that step. (20 Pts) Sorry this ir all Over the plau... ( tricd to draN Prth но
Propose a malonic ester synthesis to generate each of the following carboxylic acids pose a malonic ester synthesis to generate each of the following carboxylic acids: -OH OO COH
28- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis; Michael Addition; Malonic Ester Synthesis; Robinson Annulation; Aldol Condensation; Claisen Condensation; Intramolecular Aldol Condensation; Dieckmann Condensation or a Combination of two of the above listed reaction. In each case write the proper of the reaction on the line and dissect the product into appropriate starting material. In some cases there might only be one starting material. You may use any one of the above...
10. Select the compound that can not be made using the malonic ester synthesis: O o O OH MeO OMe OH Ph ОН A. B. Ph C. D. 11. In general both the malonic ester and acetoacetate synthesis require the addition of dilute acid in order to generate the final product. Why? A. the alkoxy cation needs to be eliminated C. the ionized cation partitions to the aqueous layer B. the stabilized enolate adds a proton in the separatory funnel...